Double C2-like domain-containing protein beta (DOC2B)

Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids at a calcium-dependent manner and might act at the priming stage of fusion by modifying membrane curvature to stimulate fusion.

Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).