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Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).
|Sequence:||17; NC_000017.11 (142789..181650, complement)|
Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Translocates to the plasma membrane in a calcium-dependent manner.