Anti-DYRK2 Antibody

DYRK2 antibody

Boster Bio Anti-DYRK2 Antibody (Catalog # A03498). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Product Info Summary

SKU: A03498
Size: 0.1 mg
Reactive Species: Human
Host: Rabbit
Application: ELISA, IF, ICC, WB

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Product Name

Anti-DYRK2 Antibody

View all DYRK2 Antibodies

SKU/Catalog Number

A03498

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-DYRK2 Antibody (Catalog # A03498). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Storage & Handling

DYRK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-DYRK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03498)

Host

Rabbit

Contents

DYRK2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

SK7

Isotype

IgG

Immunogen

DYRK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DYRK2. The immunogen is located within amino acids 520 - 570 of DYRK2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Two isoforms of DYRK2 are known to exist; this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.

Reactive Species

A03498 is reactive to DYRK2 in Human

Applications

A03498 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

66.652kDa

Background of DYRK2

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

DYRK2 antibody can be used for detection of DYRK2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For DYRK2 (Source: Uniprot.org, NCBI)

Gene Name

DYRK2

Full Name

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Weight

66.652kDa

Superfamily

protein kinase superfamily

Alternative Names

dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; EC 2.7.12; EC 2.7.12.1; FLJ21217; FLJ21365 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 dual specificity tyrosine-phosphorylation-regulated kinase 2|dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on DYRK2, check out the DYRK2 Infographic

DYRK2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for DYRK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A03498-0.1 mg

0.1 mg

$449

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