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EPAS1 Antibodies
AND EPAS1 ELISA kits, EPAS1 Proteins
Many biological assays use antibodies to detect EPAS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EPAS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EPAS1 antibodies...
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EPAS1 Infographic by Boster Bio
All EPAS1 Products
Product
Figures
Specificity
Applications
Price
Anti-HIF-2-alpha/EPAS1 Antibody Picoband®
1 Citations 4 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1129-2
100 μg/vial
Cat # PA1129-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M01248
100 μl
Cat # M01248
100 μl
Anti-HIF-2 Alpha EPAS1 Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$405
Cat # A01248
100ul
Cat # A01248
100ul
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A01248-1
100 μg/vial
Cat # A01248-1
100 μg/vial
EPAS1 Overview
Facts about Endothelial PAS domain-containing protein 1.
Endothelial PAS domain-containing protein 1 (EPAS1)
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity).
Regulates the vascular endothelial growth factor (VEGF) expression and appears to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPAS1 |
| Uniprot: | Q99814 |
| Entrez: | 2034 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
anti hif 2 alpha; HIF-2 alpha; Basic-helix-loop-helix-PAS protein MOP2; BHLHE73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain-containing protein 1; EPAS1; EPAS-1; HIF 2A; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF2 alpha; HIF-2 alpha; hif2a angiogenesis; HIF2A; HIF-2-alpha; HIF2-alpha; HLF; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; MOP2; PAS domain-containing protein 2; PASD2
Molecular Weight
Mass (kDA):
96.459 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p21 |
| Sequence: | 2; NC_000002.12 (46297407..46386697) |
Tissue Specificity
Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
Subcellular Localizations
Nucleus. Nucleus speckle. Colocalizes with HIF3A in the nucleus and speckles.
Diseases
- Hypoxia
- Tumor Angiogenesis
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Anoxia
- Pathologic Neovascularization
- Cell Invasion
- Renal Cell Carcinoma
- Degenerative Polyarthritis
- Pheochromocytoma
- Altitude Sickness
- Tissue Adhesions
Interacting Proteins
- ARNT
- BBS4
- EGLN1
- EIF3E
- EIF4E2
- FBP1
- MAX
- SMAD3
- SP1
- USP8
Pathways
- Angiogenesis
- Response To Hypoxia
- Pathogenesis
- Transport
- Cellular Response To Hypoxia
- Cell Adhesion
- Cell Differentiation
- Cell Proliferation
- Regeneration
- Oxygen Homeostasis
- Ossification
- Endochondral Ossification
- Regulation Of Angiogenesis
PTMs
- Phosphorylation
- Hydroxylation
Research Areas
- Angiogenesis
- Apoptosis
- Cancer
- Cancer Stem Cells
- Chromatin Research
- HIF Target Genes
- Hypoxia
- Lipid and Metabolism
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPAS1
bosterbio.com/bosterbio-gene-info-cards/EPAS1
References
PMID: 9000051 by Tian H., et al. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
PMID: 9079689 by Hogenesch J.B., et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
2 Publications of Boster EPAS1 Antibodies & ELISA Kits
- PubMed ID: 33155655, Wang P,Meng QQ,Wang W,Zhang S,Xiong X,Qin S,Zhang J,Li A,Liu Z. Icariin inhibits...
- PubMed ID: 27163719, Proper autophagy is indispensable for angiogenesis during chick embryo developme...
*More publications can be found for each product on its corresponding product page