ERCC6 Antibodies

Chimeric ERCC6-PGBD3 protein (ERCC6)

Involved in repair of DNA damage after UV irradiation, acting in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression.

In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6.

Gene Information

Human
Gene Name:	ERCC6
Uniprot:	P0DP91
Entrez:	2074

Family

Belongs to:
No superfamily

Alternative Names

ARMD5; ATP-dependent helicase ERCC6; CKN2; Cockayne syndrome group B protein; Cockayne syndrome protein CSB; COFS; COFS1; CSBCockayne syndrome B protein; DNA excision repair protein ERCC-6; EC 3.6.1; EC 3.6.4.-; excision repair cross-complementing rodent repair deficiency, complementationgroup 6; Rad26 homolog; RAD26

Molecular Weight

Mass (kDA):
119.487 kDA

Genomic Context

Human
Location:	10q11.23
Sequence:	10; NC_000010.11 (49454470..49539538, complement)

Tissue Specificity

Expressed in heart and oocytes, but not in granulosa cells (at protein level).

Subcellular Localizations

Nucleus.

Diseases

• Cockayne Syndrome
• Malignant Neoplasms
• Neoplasms
• Hereditary Diseases
• Xeroderma Pigmentosum
• Premature Aging Syndrome
• Xeroderma
• Carcinoma
• Skin Neoplasms
• Cachexia
• Dwarfism
• Malignant Neoplasm Of Lung

• Microcephaly
• Carcinogenesis
• Neurodegenerative Disorders
• Cell Transformation, Neoplastic
• Nerve Degeneration
• Malignant Neoplasm Of Skin

Pathways

• Dna Repair
• Aging
• Hypersensitivity
• Chromatin Remodeling
• Cell Proliferation
• Cell Cycle
• Cell Death
• Pathogenesis
• Mismatch Repair
• Methylation
• Nucleotide-excision Repair
• Localization
• Dna Excision

• Rna Interference
• Response To Oxidative Stress
• Dna Methylation
• Dna Replication
• Atp-dependent Chromatin Remodeling
• Metaphase
• Regulation Of Dna Repair

PTMs

• Phosphorylation
• Methylation
• Ubiquitination

• Dephosphorylation
• Phosphorothioation
• Acetylation

• Oxidation

Research Areas

• Cancer
• DNA Repair
• Nucleotide Excision Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC6

Boster Bio - Best Uses Of The ERCC6 Marker

In this article, I'll go over what the ERCC6L is and what its best uses are. I'll also explain how scientists can submit samples of their species and applications for the ERCC6 marker. Boster's results can be used in many industries and are available to all scientists around the globe. Read on to discover more! Remember that ERCC6L is an DNA helicase.

ERCC6L, a DNA helicase

The function of ERCC6L is unknown but it is thought to regulate the cell cycle, and also affects apoptosis. The absence of ERCC6L leads to abnormalities on chromosomes like chromatin bridges and micronuclei. PLK1 is a key regulator of numerous biological processes within the cell. This includes cell proliferation and apoptosis as metabolic processes in the cell. The knockdown of PLK1 can also increase cell proliferation and lead to cancer.

Numerous epigenetic and genetic alterations of ERCC6L have been linked to cancer risk. Genetic polymorphisms in ERCC6L have been associated with colorectal, lung, and laryngeal cancer. Additionally there is a correlation between ERCC6L and TP53 mutation. These findings also confirm the role played by ERCC6L in cancer prevention.

ERCC6L is expressed in breast cancer cells. APM2 helps to regulate transcription factors. Although it has been shown to be associated with malignancy in different types of cancers, its role in HCC is not clear. However, a recent study showed a relationship between ERCC6L expression and chemosensitivity CDDP. It is important to note that APM2 expression could be a major factor in the development of resistance to CDDP.

Numerous studies have demonstrated that ERCC6L levels are associated with HCC prognosis. A study of HCC patients showed that low and high levels of expression were significantly associated with TNM stage and disease stage. This gene could be a promising biomarker that could improve the prognosis of HCC patients. This could help patients who are undergoing treatment to decide.

ERCC6L is a recently discovered DNA helicase that was found to be highly expressed in various human cancers. However its role in colorectal cancer remains unclear. The current study investigated the role played by ERCC6L in the treatment of colorectal cancer by measuring the levels of the protein in CRC-matched tumors and non-cancerous tissue. It is crucial that ERCC6L loss does not increase the size or number of apoptotic cell populations.

CRC tissues and cancer cell line lines showed elevated expression of ERCC6L. Although the gene was associated with the size of tumors in these patients but no other clinical signs were observed. In vitro tumor growth was inhibited by siRNA knockdowns of ERCC6L. This gene is a possible cancer target and still requires validation. Xu Liu was a great help to the authors with the manuscript.

ERCC6L belongs to the SNF2 gene family and plays an important role in nucleotide excision repairs. It also recruits MAD2 to kinetochores as well as associates with catenated DNA during anaphase. Chromosomal integrity is affected by genetic anomalies in the ERCC6L genes. Furthermore this gene is vital to cell growth, differentiation, and division.

It is unclear what role ERCC6L is involved in the growth of cancerous cells. It could, however, be a powerful biomarker of cancer progression. Its role in CRC requires further study. ERCC6L has been proven to increase cell invasion and block cancer cell growth. Therefore, if the gene is downregulated in cancer cells, it may be a key target for CRC therapy.

In this study, we evaluated ERCC6L expression in CRC tissues using immunohistochemistry, western blot analysis, and reverse transcription-quantitative polymerase chain reaction. The expression of ERCC6L was associated with tumor size suggesting that it could play a role in cancer development. Our results indicate that ERCC6L could be a helpful biomarker in HCC patients.

Many helicases share similar structures and functions. Certain helicases are known to bind ATP and NTP, while others have neither. However it is true that the RGG motif isn't found in all DNA-helicases , and it is not found in any other proteins. This suggests that the RGG motif may be a crucial structural requirement for a DNA helicase. In addition to ERCC6L human p68, Drosophila VASA have a highly conserved helicase motif.

A new protein, ERCC6L, is another DNA Helicase. It plays two distinct roles in DNA repair. The helicase binds DNA of the 5'-to-3' Polarity. It is also vital in stopping DNA replication. It also allows cells to produce a molecule made of DNA and RNA. It is important to understand that the function of ERCC6L is highly dependent on the presence of the enzyme.

It is a DNA Helicase

In a recent study, researchers have identified a novel gene, ERCC6L, which is not a typical NER factor but acts as a marker for the chromosomal segment that contains active genes. Although ERCC6 is not an essential role in cell viability, it is essential for sister segregation of chromatids. The gene was once known as CSB. However, this name has been changed.

The gene is situated in the cytoplasm. It binds with DNA and regulates cell division. Its function in the DNA helicase process is vital for the preservation of the chromatin structure. DNA helicases play a vital role in maintaining DNA structure and function. The integrity of DNA molecules is maintained by the proteins involved in converting DNA into RNA. ERCC6 is the only gene of the human genome that has this feature.

The ERCC6 gene encodes a protein called Cockayne syndrome B. This protein is involved in repairing damaged DNA. It also appears to play a significant role in gene transcription the first step in the production of proteins. It regulates chromosome integrity. This may explain why it can be associated with tumorigenesis. It is therefore essential to determine if ERCC6L is associated with a particular type.

The genetic studies of ERCC6 have revealed that a genetic variant in ERCC6 is associated with lower risk of gastric cancer. Researchers also discovered a connection between a particular genotype of ERCC6 and the risk of bladder cancer in the Central Taiwanese. This association was not observed in conjunction with either ERCC6 codon 1097, or ERCC8 polymorphisms.

Numerous studies have proven that ERCC6L expression is linked to tumor growth. ERCC6L overexpression is also associated with the growth of tumors, suggesting that it could be a biomarker to detect this type of disease. Further research should investigate the mechanisms through which ERCC6L enhances the cell cycle as well as identify regulatory signaling pathways. ERCC6L could be a promising biomarker for CRC.

DNA Helicases are responsible for unwinding DNA in an ATP-dependent manner. Unwinding DNA is an essential step in many fundamental cell processes. RecQ helicases comprise one of the most conserved three'-5' DNA-helicase families. RecQ protein is named after Escherichia Coli RecQ and plays an important part in many of the cellular processes.

ERCC6 is an indicator of DNA helix. It was difficult to identify for a long time. Researchers have been able to identify the functions of the gene which encodes E. coli DNA helicase 2. They have found it. Dr. S. Matson donated the gene to the University of North Carolina. Find out more about the helicase ERCC6.

This gene is connected to Cockayne syndrome. This disorder is caused by mutations in ERCC6. ERCC6 is well-known for its ATPase activity. However contrary studies have been published on how ATP concentration affects this process. In addition, ERCC6L is associated with increased tumor size and may suggest that the overexpression of ERCC6 is responsible for Cockayne syndrome.