Forkhead box protein E1 Antibodies

Forkhead box protein E1 (FOXE1)

Transcription factor that binds consensus websites on many different gene promoters and activate their transcription. Involved in appropriate palate formation, most likely through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription element.

Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.

Gene Information

Human
Gene Name:	FOXE1
Uniprot:	O00358
Entrez:	2304

Family

Belongs to:
No superfamily

Alternative Names

FKHL15HFKL5; forkhead box E1 (thyroid transcription factor 2); forkhead box E2; Forkhead box protein E2; forkhead, drosophila, homolog-like 15; Forkhead-related protein FKHL15; HFKH4Thyroid transcription factor 2; TITF2HNF-3/fork head-like protein 5; TTF2forkhead box protein E1; TTF-2FOXE2

Molecular Weight

Mass (kDA):
38.076 kDA

Genomic Context

Human
Location:	9q22.33
Sequence:	9; NC_000009.12 (97853226..97856717)

Tissue Specificity

Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.

Subcellular Localizations

Nucleus.

Diseases

• Hypothyroidism
• Congenital Abnormality
• Congenital Hypothyroidism
• Malignant Neoplasms
• Cleft Palate
• Carcinoma
• Neoplasms
• Malignant Neoplasm Of Thyroid
• Thyroid Neoplasm
• Congenital Absence
• Cleft Lip
• Choanal Atresia

• Atresia
• Thyroid Diseases
• Hypoplasia
• Papillary Thyroid Carcinoma
• Malignant Neoplasm Of Pancreas
• Malignant Neoplasm Of Breast
• Malignant Squamous Cell Neoplasm

Interacting Proteins

• ELK1

Pathways

• Methylation
• Pathogenesis
• Cell Differentiation
• Dna Methylation
• Tissue Homeostasis
• Transport
• Cell Cycle
• Gland Morphogenesis
• Localization
• Hair Follicle Morphogenesis
• Cell Proliferation
• Cell Growth
• Secretion

• Dna Hypermethylation
• Aging
• Fertilization
• Immune Response
• Cell Fate Determination
• Hypersensitivity
• Palate Development

PTMs

• Methylation
• Demethylation
• Phosphorylation

• Cleavage
• Acetylation
• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXE1

Best Uses of the FOXE1 Marker

If you're interested in finding the best antibody for this gene, read Boster Bio: Best Uses of the FOXE1 Marker. This biographical piece describes Steven Boster, his antibodies, and his company. The FOXE1 marker is the best available antibody to detect this gene in mouse models. The antibody provides high-affinity binding to human cells. Moreover, it is validated by Western blotting, immunohistochemistry, and ELISA assays.

His research

The results of His research on the FOXE1 marker are compelling. The gene's occurrence in thyroid cancer is consistent with other findings in genetic studies. However, despite the positive correlation, FOXE1 mutations are not specific to thyroid cancer. There are many other genes and SNPs that might explain this association. The study results of one such researcher have already been published. These are the first publications to demonstrate a genetic link between FOXE1 mutations and thyroid cancer.

His antibodies

The best uses of the FOXE1 marker involve its ability to detect direct differentiation in cells. This marker is found on a variety of cell types, from normal to cancerous. The anti-rFoxE1 antibody was a gift from R. Di Lauro. Using the same primers as anti-rFoxA1, anti-rFoxE1 antibody was used to detect the target protein.