Glucokinase regulatory protein (GCKR)

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with jumped fructose 6- phosphate has increased affinity for GCK, whilst GCKR with jumped fructose 1-phosphate has strongly decreased affinity for GCK and doesn't inhibit GCK activity.