GCKR Antibodies

AND GCKR ELISA kits, GCKR Proteins

Many biological assays use antibodies to detect GCKR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GCKR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GCKR antibodies...

We validate the specificity of these antibodies to GCKR by testing them on tissues known to express GCKR positively and negatively. Browse below to find the GCKR antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GCKR Infographic by Boster Bio

All GCKR Products

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Product

Figures

Specificity

Applications

Price

Glucokinase Regulator Colorimetric Cell-Based ELISA

Human, Mouse, Rat

ELISA

$480
Cat # EKC1808
1 kit, containing one 96-well plate and all necessary reagents

Anti-Glucokinase regulatory protein GCKR Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02122
100ul

GCKR (NM_001486) Human Recombinant Protein

$813
Cat # PROTQ14397
20 µg

Anti-GCKR Mouse Monoclonal Antibody [Clone ID: OTI1E7]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M02122
100 µl

Anti-GCKR Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A02122-2
100 μg/vial

GCKR (NM_001486) Human Over-expression Lysate

Human

$960
Cat # LS002646
100 µg

GCKR Overview

Facts about Glucokinase regulatory protein.

GCKR 3D structure. Source: alphafold

Glucokinase regulatory protein (GCKR)

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with jumped fructose 6- phosphate has increased affinity for GCK, whilst GCKR with jumped fructose 1-phosphate has strongly decreased affinity for GCK and doesn't inhibit GCK activity.

Gene Information

Human
Gene Name:	GCKR
Uniprot:	Q14397
Entrez:	2646

Family

Belongs to:

GCKR family

Alternative Names

FGQTL5; GKRP; glucokinase (hexokinase 4) regulator; glucokinase (hexokinase 4) regulatory protein; Glucokinase regulator; glucokinase regulatory protein

Molecular Weight

Mass (kDA):
68.685 kDA

Genomic Context


Human

Location:	2p23.3
Sequence:	2; NC_000002.12 (27496839..27523689)

Tissue Specificity

Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.

Subcellular Localizations

Cytoplasm. Nucleus. Mitochondrion. Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Obesity
Cardiovascular Diseases
Insulin Resistance
Hyperglycemia
Dyslipidemias
Dysequilibrium Syndrome
Metabolic Syndrome X
Insulin Sensitivity
Hypertensive Disease
Chronic Kidney Disease
Inflammation

Kidney Diseases
Impaired Glucose Tolerance
Coronary Heart Disease
Heart Diseases
Kidney Failure, Chronic
Gout
Infarction

Interacting Proteins

Pathways

Glucose Homeostasis
Secretion
Insulin Secretion
Localization
Glomerular Filtration
Glycolysis
Transport
Pathogenesis
Nuclear Export
Aging
Gluconeogenesis
Translation
Nuclear Import

Response To Metformin
Immune Response
Regulation Of Gene Expression
Liver Regeneration
Interphase
Hemostasis
Cell Proliferation

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCKR

References

PMID: 8589523 by Warner J.P., et al. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.

PMID: 9570959 by Hayward B.E., et al. Organization of the human glucokinase regulator gene GCKR.