GPHB5 Antibodies

AND GPHB5 ELISA kits, GPHB5 Proteins

Many biological assays use antibodies to detect GPHB5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPHB5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPHB5 antibodies...

We validate the specificity of these antibodies to GPHB5 by testing them on tissues known to express GPHB5 positively and negatively. Browse below to find the GPHB5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPHB5 Infographic by Boster Bio

All GPHB5 Products

Product

Figures

Specificity

Applications

Price

GPHB5 Thyrostimulin Beta Human Recombinant Protein

Human

$250
Cat # PROTQ86YW7
2ug, 10ug, 1mg

GPHB5 Overview

Facts about Glycoprotein hormone beta-5.

GPHB5 3D structure. Source: alphafold

Glycoprotein hormone beta-5 (GPHB5)

Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), resulting in increased cAMP production. Plays a central role in controlling thyroid cell metabolism.

Gene Information

Human
Gene Name:	GPHB5
Uniprot:	Q86YW7
Entrez:	122876

Family

Belongs to:

glycoprotein hormones subunit beta family

Alternative Names

Glycoprotein hormone beta-5

Molecular Weight

Mass (kDA):
14.232 kDA

Genomic Context


Human

Location:	14q23.2
Sequence:	14; NC_000014.9 (63312835..63318935, complement)

Tissue Specificity

Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs.

Subcellular Localizations

Secreted.

Interacting Proteins

GPHA2

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPHB5

References

PMID: 12045258 by Nakabayashi K., et al. Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.

PMID: 12089349 by Hsu S.Y., et al. Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.