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- Table of Contents
HAVCR2 Antibodies
AND HAVCR2 ELISA kits, HAVCR2 Proteins
Many biological assays use antibodies to detect HAVCR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HAVCR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HAVCR2 antibodies...
Designing a Western blot for HAVCR2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HAVCR2 Western Blot GuideHAVCR2 Infographic by Boster Bio
All HAVCR2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # FEK1644
96 wells/kit, with removable strips.
Cat # FEK1644
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK1644
96 wells/kit, with removable strips.
Cat # EK1644
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1645
96 wells/kit, with removable strips.
Cat # EK1645
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00657-4
100 μg
Cat # M00657-4
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00657-3
100 μg
Cat # M00657-3
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00657-2
100 μg
Cat # M00657-2
100 μg
Human
ELISA, Flow Cytometry, IF, IHC-P, ICC, WB
$481
Cat # M00657
0.1 mg
Cat # M00657
0.1 mg
HAVCR2 Overview
Facts about Hepatitis A virus cellular receptor 2.
Hepatitis A virus cellular receptor 2 (HAVCR2)
Cell surface receptor implicated in modulating innate and adaptive immune responses. Reports on stimulating functions imply that the activity may be affected by the cellular context and/or the respective ligand (PubMed:24825777).
Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF- kappaB and NFAT promoter activities causing the loss of IL-2 secretion.
Gene Information
| Human | |
|---|---|
| Gene Name: | HAVCR2 |
| Uniprot: | Q8TDQ0 |
| Entrez: | 84868 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
CD366; FLJ14428; HAVCR2; HAVcr-2; hepatitis A virus cellular receptor 2; kidney injury molecule-3; KIM-3; SPTCL; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; TIM 3; TIM3 T-cell membrane protein 3; TIM3; TIM-3; TIMD3; TIMD-3; TIMD3KIM-3
Molecular Weight
Mass (kDA):
33.394 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.3 |
| Sequence: | 5; NC_000005.10 (157085832..157109044, complement) |
Tissue Specificity
Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up- regulated on HIV-1-specific CD8 T-cells.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Cell junction. Cell membrane. Localizes to the immunological synapse between CD8+ T-cells and target cells.
Diseases
- Autoimmune Reaction
- Neoplasms
- Autoimmune Diseases
- Inflammation
- Virus Diseases
- Exhaustion
- Malignant Neoplasms
- Asthma
- Autoimmunity
- Hepatitis
- Infective Disorder
- Multiple Sclerosis
- Sclerosis
Interacting Proteins
- CEACAM1
Pathways
- Pathogenesis
- Immune Response
- Cytokine Production
- Cell Death
- Secretion
- Cell Proliferation
- Cell Differentiation
- Macrophage Activation
- Phagocytosis
- Tolerance Induction
- Viral Replication
- Lymphocyte Activation
- Cytokine Secretion
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HAVCR2
bosterbio.com/bosterbio-gene-info-cards/HAVCR2
References
PMID: 11823861 by Monney L., et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
PMID: 14556005 by Sanchez-Fueyo A., et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.