This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Probable E3 ubiquitin-protein ligase HERC1.
Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also function as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Human | |
---|---|
Gene Name: | HERC1 |
Uniprot: | Q15751 |
Entrez: | 8925 |
Belongs to: |
---|
No superfamily |
EC 6.3.2; guanine nucleotide exchange factor p532; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1(CHC1)-like domain (RLD) 1; hect domain and RCC1-like domain 1; HECT domain and RCC1-like domain-containing protein 1; p532probable E3 ubiquitin-protein ligase HERC1; p619EC 6.3.2.-
Mass (kDA):
532.228 kDA
Human | |
---|---|
Location: | 15q22.31 |
Sequence: | 15; NC_000015.10 (63608618..63833948, complement) |
Widely expressed.
Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Recruited onto actin-rich surface protrusions.
PMID: 8861955 by Rosa J.L., et al. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.
PMID: 9233772 by Rosa J.L., et al. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.