HERC1 Antibodies

AND HERC1 ELISA kits, HERC1 Proteins

Many biological assays use antibodies to detect HERC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HERC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HERC1 antibodies...

We validate the specificity of these antibodies to HERC1 by testing them on tissues known to express HERC1 positively and negatively. Browse below to find the HERC1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HERC1 Infographic by Boster Bio

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HERC1 Overview

Facts about Probable E3 ubiquitin-protein ligase HERC1.

Probable E3 ubiquitin-protein ligase HERC1 (HERC1)

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP.

Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also function as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Gene Information

Human
Gene Name:	HERC1
Uniprot:	Q15751
Entrez:	8925

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2; guanine nucleotide exchange factor p532; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1(CHC1)-like domain (RLD) 1; hect domain and RCC1-like domain 1; HECT domain and RCC1-like domain-containing protein 1; p532probable E3 ubiquitin-protein ligase HERC1; p619EC 6.3.2.-

Molecular Weight

Mass (kDA):
532.228 kDA

Genomic Context


Human

Location:	15q22.31
Sequence:	15; NC_000015.10 (63608618..63833948, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Recruited onto actin-rich surface protrusions.

Diseases

Neoplasms
Malignant Neoplasms
Sclerosis
Carcinoma
Colorectal Cancer
Cell Transformation, Neoplastic
Angelman Syndrome
Tuberous Sclerosis
Stomach Neoplasms
Primary Lateral Sclerosis
Ataxia
Neuromuscular Diseases

Amyotrophic Lateral Sclerosis
Protein Deficiency
Pruritus
Lichen Disease
Hamartoma
Cytopathic Effect

Pathways

Cell Cycle
Transport
Cell Proliferation
Localization
Cytokinesis
Drug Resistance
Mismatch Repair
Translation
Cell Growth

Chromosome Condensation
Pathogenesis
Autophagy
Oncogenesis

PTMs

Phosphorylation

Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HERC1

References

PMID: 8861955 by Rosa J.L., et al. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.

PMID: 9233772 by Rosa J.L., et al. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.