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- Table of Contents
Facts about Potassium voltage-gated channel subfamily D member 2.
This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials in the neuronal cell body to the dendrites.
Human | |
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Gene Name: | KCND2 |
Uniprot: | Q9NZV8 |
Entrez: | 3751 |
Belongs to: |
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potassium channel family |
potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; voltage-gated potassium channel Kv4.2; voltage-sensitive potassium channel
Mass (kDA):
70.537 kDA
Human | |
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Location: | 7q31.31 |
Sequence: | 7; NC_000007.14 (120273175..120750337) |
Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204).
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell junction, synapse. Perikaryon. Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Cell junction. In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when
Using high-affinity primary antibodies for the detection of KCND2 is the most effective way to perform experiments in a wide variety of biological systems. Boster antibodies can target multiple protein targets at once, thereby allowing researchers to test multiple proteins at once. These antibodies can be obtained through a variety of methods, including high-affinity ELISA, immunofluorescence, and flow cytometry.
KCND2 is a nuclear receptor expressed in the brain. The antibody was designed to recognize this receptor, which is expressed in both neurons and glia. The antibody was used in a double-layer immunoblotting technique. A secondary antibody was conjugated to goat anti-dIG (HRP). The lysates were visualized using an enhanced chemiluminescence kit on a Leica TCS SP2 confocal microscope.
PMID: 9843794 by Kong W., et al. Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.
PMID: 10551270 by Zhu X.-R., et al. Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current.