KCND2 Antibodies

Potassium voltage-gated channel subfamily D member 2 (KCND2)

Voltage-gated potassium channel that mediates transmembrane potassium transfer in excitable membranes, primarily in the brain. Mediates the significant part of the dendritic A-type present I(SA) in brain neurons (By similarity).

This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials in the neuronal cell body to the dendrites.

Gene Information

Human
Gene Name:	KCND2
Uniprot:	Q9NZV8
Entrez:	3751

Family

Belongs to:
potassium channel family

Alternative Names

potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; voltage-gated potassium channel Kv4.2; voltage-sensitive potassium channel

Molecular Weight

Mass (kDA):
70.537 kDA

Genomic Context

Human
Location:	7q31.31
Sequence:	7; NC_000007.14 (120273175..120750337)

Tissue Specificity

Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell junction, synapse. Perikaryon. Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Cell junction. In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when

Diseases

• Cardiac Arrhythmia
• Hypertrophy
• Cardiac Hypertrophy
• Long Qt Syndrome
• Heart Failure
• Diabetes Mellitus
• Hypothyroidism
• Hypertensive Disease
• Epilepsy
• Diabetes Mellitus, Experimental
• Infarction
• Myocardial Infarction
• Cardiomyopathies

• Hypoxia
• Torsades De Pointes
• Epilepsy, Temporal Lobe
• Hyperthyroidism
• Heart Diseases
• Depressive Disorder
• Nervousness

Interacting Proteins

• KCNIP1
• KCNIP2

Pathways

• Localization
• Pathogenesis
• Transport
• Cell Death
• Cell Activation
• Sensory Processing
• Parturition
• Response To Camp
• T Cell Activation
• Ion Transport
• Synaptic Transmission
• Membrane Depolarization

• Reverse Transcription
• Translation
• Cell Differentiation
• Cell Growth
• Protein Stabilization
• Secretion

PTMs

• Phosphorylation
• Biotinylation
• Reduction
• Phosphorothioation

• Cleavage
• Gamma-cleavage
• Acylation
• Palmitoylation

• Myristoylation

Research Areas

• Neuronal Cell Markers
• Neuroscience
• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCND2

Best Uses Of The KCND2 Marker

Using high-affinity primary antibodies for the detection of KCND2 is the most effective way to perform experiments in a wide variety of biological systems. Boster antibodies can target multiple protein targets at once, thereby allowing researchers to test multiple proteins at once. These antibodies can be obtained through a variety of methods, including high-affinity ELISA, immunofluorescence, and flow cytometry.

High-affinity primary antibodies

KCND2 is a nuclear receptor expressed in the brain. The antibody was designed to recognize this receptor, which is expressed in both neurons and glia. The antibody was used in a double-layer immunoblotting technique. A secondary antibody was conjugated to goat anti-dIG (HRP). The lysates were visualized using an enhanced chemiluminescence kit on a Leica TCS SP2 confocal microscope.