This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Kallikrein-14.
May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a procedure by which the most superficial corneocytes are shed from the skin surface.
Human | |
---|---|
Gene Name: | KLK14 |
Uniprot: | Q9P0G3 |
Entrez: | 43847 |
Belongs to: |
---|
peptidase S1 family |
EC 3.4.21; EC 3.4.21.-; hK14; Kallikrein 14; Kallikrein-like protein 6; kallikrein-related peptidase 14; KLK14; KLKL6; KLK-L6kallikrein-14
Mass (kDA):
29.122 kDA
Human | |
---|---|
Location: | 19q13.41 |
Sequence: | 19; NC_000019.10 (51077494..51084210, complement) |
Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level).
Secreted, extracellular space.
PMID: 11309303 by Yousef G.M., et al. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.
PMID: 11352573 by Hooper J.D., et al. Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.