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KCNN4 Antibodies
AND KCNN4 ELISA kits, KCNN4 Proteins
Many biological assays use antibodies to detect KCNN4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNN4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNN4 antibodies...
Designing a Western blot for KCNN4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KCNN4 Western Blot GuideKCNN4 Infographic by Boster Bio
All KCNN4 Products
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KCNN4 Overview
Facts about Intermediate conductance calcium-activated potassium channel protein 4.
Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which boosts calcium influx.
Required for maximum calcium influx and proliferation throughout the reactivation of innocent T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNN4 |
| Uniprot: | O15554 |
| Entrez: | 3783 |
Family
| Belongs to: |
|---|
| potassium channel KCNN family |
Alternative Names
hIKCa1; hKCa4; hSK4; IK1; IKCa1; intermediate conductance calcium-activated potassium channel protein 4; KCa3.1IKCA1; KCa4; KCA4SKCa4; potassium intermediate/small conductance calcium-activated channel, subfamilyN, member 4; putative erythrocyte intermediate conductance calcium-activated potassiumGardos channel; Putative Gardos channel; SK4SKCa 4
Molecular Weight
Mass (kDA):
47.696 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.31 |
| Sequence: | 19; NC_000019.10 (43766533..43782139, complement) |
Tissue Specificity
Widely expressed in non-excitable tissues.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Fibrosis
- Cystic Fibrosis
- Anemia, Sickle Cell
- Autoimmune Reaction
- Dehydration
- Malignant Neoplasms
- Autoimmune Diseases
- Retinoblastoma
- Inflammation
- Infarction
- Brain Injuries
- Anemia
- Multiple Sclerosis
Interacting Proteins
- CFTR
- PHPT1
Pathways
- Secretion
- Transport
- Cell Proliferation
- Cell Activation
- Cell Cycle
- Ion Transport
- Localization
- Membrane Hyperpolarization
- Pathogenesis
- Cell Migration
- Cell Differentiation
- Immune Response
- Cytokine Production
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNN4
bosterbio.com/bosterbio-gene-info-cards/KCNN4
References
PMID: 9380751 by Joiner W.J., et al. hSK4, a member of a novel subfamily of calcium-activated potassium channels.
PMID: 9326665 by Ishii T.M., et al. A human intermediate conductance calcium-activated potassium channel.