Overview
| Product Name |
Anti-KCNN4 Antibody
See all KCNN4 primary antibodies, ELISA kits and proteins |
| SKU/Catalog Number |
PA1047-1 |
| Pack Size |
100μg/vial |
| Storage & Handling |
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing. |
| Description |
Polyclonal antibody for IK1/KCNN4 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. IK1/KCNN4 information: Molecular Weight: 47696 MW; Subcellular Localization: Membrane; Multi-pass membrane protein; Tissue Specificity: Widely expressed in non-excitable tissues. |
| Cite This Product |
Anti-KCNN4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1047-1)
|
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Anti-KCNN4 Antibody may replace the following items: sc 135485|sc 135487|sc 27080|sc 27081|sc 27082|sc 32949|sc 365265. |
Product Specs
| Host |
Rabbit |
| Reactivity/Species |
Human, Rat |
| Predicted Reactivity |
Bovine
*This antibody is predicted to react with the above species based on antigen
sequence similarities. Our Boster Guarantee covers the use of this product with the above species. |
| Applications |
WB
*Our Boster Guarantee covers the use of this product in the above
tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products. |
| Related Products |
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round. |
| Immunogen |
A synthetic peptide corresponding to a sequence at the N-terminus of human KCNN4(14-29aa RRKRLLEQEKSLAGWA), different from the related mouse and rat sequences by two amino acids. |
| Cross Reactivity |
No cross reactivity with other proteins |
Gene/Protein Basic Information For KCNN4 (Source: Uniprot.org, NCBI)
| Uniprot Id | O15554 |
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| NCBI Gene Id | 3783 |
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| Species Of This Entry | Human |
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| Gene Name | KCNN4 |
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| Protein Name | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Superfamily | potassium channel KCNN family |
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| Alternative Names | KCNN4|hIKCa1; hKCa4; hSK4; IK1; IKCa1; intermediate conductance calcium-activated potassium channel protein 4; KCa3.1IKCA1; KCa4; KCA4SKCa4; potassium intermediate/small conductance calcium-activated channel, subfamilyN, member 4; putative erythrocyte intermediate conductance calcium-activated potassiumGardos channel; Putative Gardos channel; SK4SKCa 4 |
|---|
| Molecular Weight | 47696 |
|---|
| Post Tranlational Modifications | Phosphorylation; Dephosphorylation; Nitration; Ubiquitination; Nitrosylation |
|---|
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
|---|
| Gene Location | 19q13.31, on Chromasome 19, gene sequence: NC_000019.10 (43766533..43782139, complement) |
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*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For KCNN4 (Source: Uniprot.org, NCBI)
| Protein Function | Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). |
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| Tissue Specificity | Widely expressed in non-excitable tissues. |
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| Interacting Proteins | CFTR; PHPT1 |
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| Related Diseases | Fibrosis; Cystic Fibrosis; Anemia, Sickle Cell; Autoimmune Reaction; Dehydration; Malignant Neoplasms; Autoimmune Diseases; Retinoblastoma; Inflammation; Infarction; Brain Injuries; Anemia; Multiple Sclerosis; Neoplasms; Cardiovascular Diseases; Diarrhea; Edema; Nervousness; Atherosclerosis; Hyperplasia |
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| Related Pathways | Secretion; Transport; Cell Proliferation; Cell Activation; Cell Cycle; Ion Transport; Localization; Membrane Hyperpolarization; Pathogenesis; Cell Migration; Cell Differentiation; Immune Response; Cytokine Production; T Cell Activation; Lymphocyte Activation; Translation; Endocytosis; Cell Death; Macrophage Activation; S Phase |
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| Background | Intermediate conductance calcium-activated potassium channel protein 1(KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. |
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| Scientific References | PMID: 9380751 by Joiner W.J., et al. hSK4, a member of a novel subfamily of calcium-activated potassium channels.
PMID: 9326665 by Ishii T.M., et al. A human intermediate conductance calcium-activated potassium channel. |
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Our Boster Quality Guarantee for Anti-KCNN4 Antibody covers its use in the following applications.
Western blot, 0.1-0.5μg/ml, Human, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Anti-KCNN antibody, PA1047-1, Western blotting
All lanes: Anti KCNN(PA1047-1) at 0.5ug/ml
WB: HUT Whole Cell Lysate at 40ug
Predicted bind size: 60KD
Observed bind size: 60KD
Specific Protocols
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
See all KCNN4 primary antibodies,
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