LATS1 Antibodies

Serine/threonine-protein kinase LATS1 (LATS1)

Negative regulator of YAP1 from the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The crux of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which then phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor that plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint.

Gene Information

Human
Gene Name:	LATS1
Uniprot:	O95835
Entrez:	9113

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); serine/threonine-protein kinase LATS1; WARTS protein kinase; WARTSEC 2.7.11.1; wts

Molecular Weight

Mass (kDA):
126.87 kDA

Genomic Context

Human
Location:	6q25.1
Sequence:	6; NC_000006.12 (149658153..149718256, complement)

Tissue Specificity

Expressed in all adult tissues examined except for lung and kidney.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.

Diseases

• Neoplasms
• Malignant Neoplasms
• Common Wart
• Cell Transformation, Neoplastic
• Carcinoma
• Mammary Neoplasms
• Hyperplasia
• Neoplasm Metastasis
• Ovarian Neoplasm
• Liver Carcinoma
• Malignant Neoplasm Of Breast
• Sarcoma

• Malignant Paraganglionic Neoplasm
• Leukemia
• Myotonic Dystrophy
• Malignant Neoplasm Of Lung
• Tissue Adhesions
• Retinoblastoma
• Adenoma

Interacting Proteins

• CDK1
• CDK2
• DCAF1
• ESR1
• LIMK1

• MOB1A
• MOB1B
• NF2
• Nf2
• NUAK1

• SIAH2
• STK11
• WWTR1
• YAP1
• ZYX

Pathways

• Cell Proliferation
• Cell Cycle
• Mitosis
• Cell Growth
• Cell Death
• Localization
• Cell Migration
• Cytokinesis
• Interphase
• Regulation Of Cell Cycle
• S Phase
• Contact Inhibition
• Methylation

• Rna Interference
• Centrosome Duplication
• Telophase
• Pathogenesis
• Cellular Senescence
• Senescence
• Regulation Of Cell Proliferation

PTMs

• Phosphorylation
• Methylation
• Ubiquitination

• Cleavage
• Dephosphorylation
• Reduction

Research Areas

• Apoptosis
• Cancer
• Cell Cycle and Replication
• Mitotic Regulators
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LATS1

Boster Bio: Best Uses Of The LATS1 Marker

The Boster Bio: Best Uses Of TheLATS1 Marker can be used in immunohistochemistry, Western blotting, and TUNEL assays. Below are a few of the most popular uses of this marker. Read on to learn more about its uses and how it can assist scientists. All scientists around the world can use it for research and development. This Boster Bio article will provide more information.

Immunohistochemistry

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References

PMID: 9988268 by Tao W., et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.

PMID: 10518011 by Nishiyama Y., et al. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis.