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- Table of Contents
Facts about Serine/threonine-protein kinase LATS1.
Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor that plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint.
Human | |
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Gene Name: | LATS1 |
Uniprot: | O95835 |
Entrez: | 9113 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); serine/threonine-protein kinase LATS1; WARTS protein kinase; WARTSEC 2.7.11.1; wts
Mass (kDA):
126.87 kDA
Human | |
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Location: | 6q25.1 |
Sequence: | 6; NC_000006.12 (149658153..149718256, complement) |
Expressed in all adult tissues examined except for lung and kidney.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
The Boster Bio: Best Uses Of TheLATS1 Marker can be used in immunohistochemistry, Western blotting, and TUNEL assays. Below are a few of the most popular uses of this marker. Read on to learn more about its uses and how it can assist scientists. All scientists around the world can use it for research and development. This Boster Bio article will provide more information.
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