MARK2 Antibodies

AND MARK2 ELISA kits, MARK2 Proteins

Many biological assays use antibodies to detect MARK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARK2 antibodies...

We validate the specificity of these antibodies to MARK2 by testing them on tissues known to express MARK2 positively and negatively. Browse below to find the MARK2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MARK2 Infographic by Boster Bio

All MARK2 Products

Product

Figures

Specificity

Applications

Price

Anti-Phospho-MARK2 T595 Antibody

5 Q&As

Human

ELISA, WB

$599
Cat # P02117
100ug

Anti-MARK2 Antibody

Human, Mouse, Rat

$405
Cat # A02117
100ul

Anti-MARK2 Antibody

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$405
Cat # A02117-1
100ul

MARK2 (NM_004954) Human Recombinant Protein

$1249
Cat # PROTQ7KZI7
20 µg

Anti-MARK2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M02117-1
100 μl/vial

MARK2 (NM_017490) Human Over-expression Lysate

Human

$960
Cat # LS002011
100 µg

MARK2 Overview

Facts about Serine/threonine-protein kinase MARK2.

MARK2 3D structure. Source: alphafold

Serine/threonine-protein kinase MARK2 (MARK2)

Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2.

Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly.

Gene Information

Human
Gene Name:	MARK2
Uniprot:	Q7KZI7
Entrez:	2011

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; ELKL motif kinase 1; ELKL motif kinase; EMK-1; EMK1PAR-1; MAP/microtubule affinity-regulating kinase 2MGC99619; PAR1 homolog; Par1b; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; serine/threonine-protein kinase MARK2

Molecular Weight

Mass (kDA):
87.911 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (63838928..63911020)

Tissue Specificity

High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite. Cytoplasm. Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.

Diseases

Neoplasms
Alzheimer's Disease
Malignant Neoplasms
Tissue Adhesions
Insulin Sensitivity
Malignant Neoplasm Of Stomach
Carcinoma
Diabetes Mellitus
Tauopathies
Carcinogenesis
Stomach Neoplasms
Diabetes Mellitus, Non-insulin-dependent
Insulin Resistance

Neuroblastoma
Nerve Degeneration
Gastritis
Obesity
Ulcer
Gastric Adenocarcinoma
Adenocarcinoma

Interacting Proteins

MAPT
PARD6G
YWHAB
YWHAG
YWHAH

YWHAZ

Pathways

Localization
Secretion
Transport
Virulence
Pathogenesis
Hyperphosphorylation
Cell Death
Mitochondrial Transport
Insulin Secretion
Glucose Homeostasis
Cell Division
Cell Motility
Cell Differentiation

Cell-cell Adhesion
Establishment Of Cell Polarity
Hypersensitivity
Transcytosis
Asymmetric Cell Division
Mitosis
Maintenance Of Cell Polarity

PTMs

Phosphorylation
Dephosphorylation
Cleavage

Ubiquitination
Citrullination
Acetylation

Myristoylation

Research Areas

Phospho-Specific
Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARK2

References

PMID: 9730619 by Espinosa L., et al. Human serine/threonine protein kinase EMK1: genome structure and cDNA cloning of isoforms produced by alternative splicing.

PMID: 11433294 by Sun T.-Q., et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.