Nuclear factor NF-kappa-B p100 subunit (NFKB2)

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to a lot of biological processes such as inflammation, immunity, differentiation, cell development, tumorigenesis and apoptosis. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B websites that they can bind with distinguishable affinity and specificity.

Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with different cofactors or corepressors.