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- Table of Contents
NAMPT Antibodies
AND NAMPT ELISA kits, NAMPT Proteins
Many biological assays use antibodies to detect NAMPT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NAMPT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NAMPT antibodies...
Designing a Western blot for NAMPT? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NAMPT Western Blot GuideDesigning an IHC experiment for NAMPT? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NAMPT IHC GuideNAMPT Infographic by Boster Bio
All NAMPT Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB10009
100 μg/vial
Cat # PB10009
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00770-1
100 μg
Cat # M00770-1
100 μg
NAMPT Overview
Facts about Nicotinamide phosphoribosyltransferase.
Nicotinamide phosphoribosyltransferase (NAMPT)
Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the NAD biosynthesis pathway.
The secreted form acts both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partially because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function.
Gene Information
| Human | |
|---|---|
| Gene Name: | NAMPT |
| Uniprot: | P43490 |
| Entrez: | 10135 |
Family
| Belongs to: |
|---|
| NAPRTase family |
Alternative Names
EC 2.4.2.12; MGC117256; NAmPRTase; NAMPT; nicotinamide phosphoribosyltransferase; NMPRTase; PBEF; PBEF1; PBEF1110035O14Rik; PBEF1DKFZp666B131; Pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; Pre-B-cell colony-enhancing factor 1; VF; Visfatin
Molecular Weight
Mass (kDA):
55.521 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.3 |
| Sequence: | 7; NC_000007.14 (106248298..106284983, complement) |
Tissue Specificity
Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Subcellular Localizations
Nucleus. Cytoplasm. Secreted. Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
Diseases
- Obesity
- Inflammation
- Malignant Neoplasms
- Diabetes Mellitus
- Insulin Resistance
- Neoplasms
- Diabetes Mellitus, Non-insulin-dependent
- Atherosclerosis
- Inflammatory Response
- Metabolic Diseases
- Malignant Paraganglionic Neoplasm
- Insulin Sensitivity
Interacting Proteins
- FTL
- IFITM3
- MT-ND1
Pathways
- Aging
- Secretion
- Pathogenesis
- Inflammatory Response
- Glucose Homeostasis
- Cell Proliferation
- Senescence
- Insulin Secretion
- Cell Growth
- Cell Death
- Angiogenesis
- Translation
- Autophagy
PTMs
- Phosphorylation
- Acetylation
- Deacetylation
- Oxidation
- Cleavage
Research Areas
- Adaptive Immunity
- Cell Cycle and Replication
- Immunology
- Innate Immunity
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NAMPT
bosterbio.com/bosterbio-gene-info-cards/NAMPT
References
PMID: 8289818 by Samal B., et al. Cloning and characterization of the cDNA encoding a novel human pre- B-cell colony-enhancing factor.
PMID: 22462624 by Dahl T.B., et al. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology.