Polycomb group RING finger protein 1 (Pcgf1)

Part of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to keep the transcriptionally repressive state of several genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted into the DNA by BCL6; this transcription repressor activity may be linked to PKC signaling pathway.

Represses CDKN1A expression by binding to its promoter, and this repression is determined by the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation too.