Anti-PCGF1 Antibody (Center)

Product Name

Anti-PCGF1 Antibody (Center)

View all Pcgf1 Antibodies

SKU/Catalog Number

A08147

Size

80 µl

Description

Boster Bio Anti-PCGF1 Antibody (Center) (Catalog # A08147). Tested in WB application(s). This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-PCGF1 Antibody (Center) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08147)

Host

Rabbit

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

This PCGF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids from the Central region of human PCGF1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A08147 is reactive to PCGF1 in Human, Mouse, Rat

Reconstitution

Calculated molecular weight

30346 Da

Background of Pcgf1

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A08147 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000

Validation Images & Assay Conditions

Gene/Protein Information For PCGF1 (Source: Uniprot.org, NCBI)

Alternative Names

Polycomb group RING finger protein 1, Nervous system Polycomb-1, NSPc1, RING finger protein 68, PCGF1, NSPC1, RNF68 Pcgf1|2010002K04Rik, AU024121, Ns, Nspc1|polycomb group ring finger 1|polycomb group RING finger protein 1|RING finger protein 68|nervous system Polycomb-1|nervous system polycomb 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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