Pituitary homeobox 2 Antibodies

Pituitary homeobox 2 (PITX2)

Controls cell proliferation in a tissue-specific fashion and is involved in morphogenesis. During embryonic development, exerts a part in the growth of muscle progenitors.

May play a role in the proper localization of asymmetric organs such as the heart and gut. Isoform PTX2C is involved in left-right asymmetry the growing embryo (By similarity).

Gene Information

Human
Gene Name:	PITX2
Uniprot:	Q99697
Entrez:	5308

Family

Belongs to:
paired homeobox family

Alternative Names

all1-responsive gene 1; ALL1-responsive protein ARP1; ARP1MGC20144; Brx1; Homeobox protein PITX2; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; paired-like homeodomain 2; Paired-like homeodomain transcription factor 2MGC111022; pituitary homeo box 2; pituitary homeobox 2; PITX2; PTX2; RGS; RGSRIEG1Brx1; rieg bicoid-related homeobox transcription factor 1; RIEG bicoid-related homeobox transcription factor; RIEG; RIEG1; RP1; RS; Solurshin

Molecular Weight

Mass (kDA):
35.37 kDA

Genomic Context

Human
Location:	4q25
Sequence:	4; NC_000004.12 (110617423..110642123, complement)

Subcellular Localizations

Nucleus.

Diseases

• Rieger Syndrome
• Pituitary Diseases
• Eye Abnormalities
• Glaucoma
• Congenital Abnormality
• Malignant Neoplasms
• Congenital Heart Defects
• Hypoplasia
• Irido-corneal Dysgenesis
• Neoplasms
• Corneal Diseases
• Crest Syndrome
• Atrial Fibrillation

• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Cardiac Fibrillation
• Tooth Abnormalities
• Congenital Absence
• Craniofacial Abnormalities
• Hydrophthalmos

Interacting Proteins

• CTNNB1
• FOXC1
• Hoxa1
• MEF2A
• Pou1f1

• YBX1

Pathways

• Methylation
• Cell Proliferation
• Heart Looping
• Pathogenesis
• Dna Methylation
• Gastrulation
• Eye Development
• Localization
• Cell Differentiation
• Cell Cycle
• Heart Development
• Organ Morphogenesis
• Odontogenesis

• Cell Growth
• Segmentation
• Eye Morphogenesis
• Heart Morphogenesis
• Neural Tube Closure
• Cell Division
• Tube Closure

PTMs

• Methylation
• Phosphorylation
• Acetylation

• Demethylation
• Carboxylation
• Dephosphorylation

Research Areas

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PITX2

Best Uses Of The PITX2 Marker

What are the most efficient uses for the PITX2 marker? There are many. Here are a few of the most common uses. These include gene infographics , as well as special examples. All of these uses are applicable to all scientists around the world. If you're looking to learn more, continue reading. There's also more information about Steven Boster (one of the co-founders) of Boster.

Boster's high-affinity primal antibodies

High-affinity antibodies are the most effective way to measure specific analytes from basic preparations. These antibodies are extremely specific and can eliminate non-specific binding substances. High-affinity antibodies are helpful in measuring specific analytes in crude preparations and have a variety of other applications in the research community. To learn more, read on to learn more about the antibodies and their unique characteristics.

To perform mIHC that is fluorescent, one or more markers are used in the mIHC. The primary antibody can be either fluorescent or nonfluorescent. Since secondary antibodies can amplify the signal, fluorescent mIHC should be done with them. The filter sets available limit fluorescent mIHC only to three markers. In addition fluorescent mIHC is dependent on primary antibodies that have been produced in different species or isotypes.

Nonspecific hooking is used to trap the detection of primary antibodies as well as secondary antibodies. This results in a background signal that reduces the signal-to noise ratio and lowers the sensitivity of the test. Hooking that is not specific is a frequent problem with primary and secondary antibodies. It can be costly and time-consuming to label and attach both antibodies. Therefore, it's recommended to use the two-step method of detecting the same antibody.

It is crucial for researchers to record every research result. To ensure the accuracy of the findings it is essential to describe the control. If there is no documentation, mistakes are likely to be made. Boster's high affinity primary antibodies employ the PITX2 marker to identify specific proteins in tissues. This technique is particularly useful when it is possible to identify the antigens from tissue by using high-affinity antibodies.

To determine the specificity of an antibody, it is essential to conduct immunohistochemistry with a control without the primary antibody. This control is used to interpret the results of primary antibody-stained sections. These results are useful, but not very useful in determining specificity. The control is simply a measure of nonspecific secondary antibody binding, and it is not a reliable indicator of the specificity of the primary antibody.

History of Steven Boster

Steve Boster's life is rife with tragedy. The death of his father forced his family to think about his future. Steve was born in Joliet in Illinois and died in Madison, Wisconsin. He was a former U.S. Army veteran, who served in Vietnam and then returned home and settled in Staunton, VA. Boster is survived by two daughters, Crystal Boster and Natosha Peck. He is also survived by five grandchildren and four of his siblings, Jack Boster (and Sandra Blanton). His son Jonathan and his grandson Cory reside in Herrin, IL.

The first product he created was in 1993. His breakthrough earned him the name "he that converts science in the toilet". He developed a variety of products that included IHC. He also developed hundreds of primary antibodies as well as an exclusive ELISA platform called PicoKine. The PicoKine platform utilizes proprietary trade secrets to provide high-sensitivity ELISA kits. PicoKine(tm) was later created by the inventor as his own ELISA platform.