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PRDM16 Antibodies
AND PRDM16 ELISA kits, PRDM16 Proteins
Many biological assays use antibodies to detect PRDM16, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRDM16 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRDM16 antibodies...
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PRDM16 Overview
Facts about Histone-lysine N-methyltransferase PRDM16.
Histone-lysine N-methyltransferase PRDM16 (PRDM16)
Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) that is specialized in dissipating chemical energy in the shape of heat in response to cold or surplus feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of adrenal gland.
Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRDM16 |
| Uniprot: | Q9HAZ2 |
| Entrez: | 63976 |
Family
| Belongs to: |
|---|
| PRDM16 family |
Alternative Names
MDS1/EVI1-like gene 1; MEL1; MEL1KIAA1675PFM13MGC166915; PFM13; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; PRDM16; Transcription factor MEL1
Molecular Weight
Mass (kDA):
140.251 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.32 |
| Sequence: | 1; NC_000001.11 (3069203..3438621) |
Tissue Specificity
Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Obesity
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Leukemogenesis
- Diabetes Mellitus
- Malignant Neoplasms
- Chromosomal Translocation
- Dysmyelopoietic Syndromes
- Neoplasms
- Nervousness
- Dysplasia
Interacting Proteins
- Ctbp2
- RBBP4
Pathways
- Pathogenesis
- Cell Differentiation
- Oncogenesis
- Energy Homeostasis
- Methylation
- Aging
- Neurogenesis
- Response To Cold
- Lipid Storage
- Cell Proliferation
- Transport
- Heterochromatin Organization
- Transposition
PTMs
- Methylation
- Oxidation
- Phosphorylation
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRDM16
bosterbio.com/bosterbio-gene-info-cards/PRDM16
References
PMID: 11050005 by Mochizuki N., et al. A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)- positive leukemia cells.
PMID: 12816872 by Nishikata I., et al. A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF- induced myeloid differentiation.