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- Table of Contents
RAC2 Antibodies
AND RAC2 ELISA kits, RAC2 Proteins
Many biological assays use antibodies to detect RAC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAC2 antibodies...
Designing a Western blot for RAC2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAC2 Western Blot GuideDesigning an IHC experiment for RAC2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RAC2 IHC GuideRAC2 Infographic by Boster Bio
All RAC2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01714-1
100 μl/vial
Cat # M01714-1
100 μl/vial
RAC2 Overview
Facts about Ras-related C3 botulinum toxin substrate 2.
Ras-related C3 botulinum toxin substrate 2 (RAC2)
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization.
Augments the production of reactive oxygen species (ROS) by NADPH oxidase. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RAC2 |
| Uniprot: | P15153 |
| Entrez: | 5880 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
Gx; HSPC022; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP bindingprotein Rac2); rho family, small GTP binding protein Rac2; small GTP-bindingprotein Rac2)
Molecular Weight
Mass (kDA):
21.429 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (37225270..37244269, complement) |
Tissue Specificity
Hematopoietic specific.
Subcellular Localizations
Cytoplasm. Membrane-associated when activated.
Diseases
- Tissue Adhesions
- Inflammation
- Leukemia
- Malignant Neoplasms
- Infective Disorder
- Neoplasms
- Cell Invasion
- Granulomatous Disease, Chronic
- Immunologic Deficiency Syndromes
- Myeloid Leukemia
- Granulomatous Disorder
- Myeloid Leukemia, Chronic
- Cell Transformation, Neoplastic
Interacting Proteins
- PLD2
- TNFAIP8L2
Pathways
- Chemotaxis
- Phagocytosis
- Localization
- Respiratory Burst
- Cell Migration
- Cell Adhesion
- Immune Response
- Neutrophil Chemotaxis
- Cell Activation
- Cell Growth
- Cell Motility
- Neutrophil Activation
- Exocytosis
PTMs
- Phosphorylation
- Prenylation
- Dephosphorylation
- Methylation
- Ribosylation
- Oxidation
- Reduction
- Cleavage
Research Areas
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAC2
bosterbio.com/bosterbio-gene-info-cards/RAC2
References
PMID: 2674130 by Didsbury J., et al. Rac, a novel ras-related family of proteins that are botulinum toxin substrates.
PMID: 1316893 by Mizuno T., et al. Regulation of the superoxide-generating NADPH oxidase by a small GTP- binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.