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- Table of Contents
Facts about E3 ubiquitin-protein ligase RAD18.
Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
Human | |
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Gene Name: | RAD18 |
Uniprot: | Q9NS91 |
Entrez: | 56852 |
Belongs to: |
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RAD18 family |
EC 6.3.2.-; hHR18; hRAD18; postreplication repair protein hRAD18p; Postreplication repair protein RAD18; RAD18 homolog (S. cerevisiae); RAD18, S. cerevisiae, homolog; RING finger protein 73; RNF73E3 ubiquitin-protein ligase RAD18
Mass (kDA):
56.223 kDA
Human | |
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Location: | 3p25.3 |
Sequence: | 3; NC_000003.12 (8877075..8969249, complement) |
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
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PMID: 10884424 by Tateishi S., et al. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.
PMID: 10908344 by Xin H., et al. The human RAD18 gene product interacts with HHR6A and HHR6B.