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RAPGEF2 Antibodies
AND RAPGEF2 ELISA kits, RAPGEF2 Proteins
Many biological assays use antibodies to detect RAPGEF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAPGEF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAPGEF2 antibodies...
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RAPGEF2 Infographic by Boster Bio
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RAPGEF2 Overview
Facts about Rap guanine nucleotide exchange factor 2.
Rap guanine nucleotide exchange factor 2 (RAPGEF2)
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP at a cAMP-dependent manner. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby resulting in the amplification of Rap1-mediated signaling.
Shows poor activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771).
Gene Information
| Human | |
|---|---|
| Gene Name: | RAPGEF2 |
| Uniprot: | Q9Y4G8 |
| Entrez: | 9693 |
Family
| Belongs to: |
|---|
| RAPGEF2 family |
Alternative Names
CNrasGEF; KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor (GEF) 1; PDZGEF1; PDZ-GEF1PDZ domain-containing guanine nucleotide exchange factor 1; RA(Ras/Rap1A-associating)-GEF; RA-GEFDKFZP586O1422; Rap guanine nucleotide exchange factor (GEF) 2; rap guanine nucleotide exchange factor 2; Rap-GEP
Molecular Weight
Mass (kDA):
167.417 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q32.1 |
| Sequence: | 4; NC_000004.12 (159104051..159360173) |
Tissue Specificity
Expressed in primary neuronal and endocrine cells (at protein level). Highest expression levels in brain. Lower expression levels in heart, kidney, lung, placenta and blood leukocytes.
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Late endosome. Cell junction. Associated with the synaptic plasma membrane. Colocalizes with ADRB1 at the plasma membrane. Synaptosome. Enriched in synaptic plasma membrane and neuronal cell body. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-depende
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Prostatic Neoplasms
- Cell Invasion
- Malignant Neoplasm Of Prostate
- Congenital Absence
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Proteinuria Of Undiagnosed Cause
- Diabetes Mellitus
- Carcinoma
- Insulin Resistance
Pathways
- Cell Adhesion
- Cell Migration
- Localization
- Photoreceptor Cell Differentiation
- Dna Methylation
- Glomerular Filtration
- Methylation
- Drug Resistance
- Axon Guidance
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAPGEF2
bosterbio.com/bosterbio-gene-info-cards/RAPGEF2
References
PMID: 10548487 by Ohtsuka T., et al. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM).
PMID: 10608844 by Liao Y., et al. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.