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Schlafen family member 11 Antibodies
AND SLFN11 ELISA kits, Schlafen family member 11 Proteins
Many biological assays use antibodies to detect Schlafen family member 11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Schlafen family member 11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Schlafen family member 11 antibodies...
Designing an IHC experiment for Schlafen family member 11? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SLFN11 IHC GuideSLFN11 Infographic by Boster Bio
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SLFN11 Overview
Facts about Schlafen family member 11.
Schlafen family member 11 (SLFN11)
Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061).
Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at worried replication forks, possibly leading to unwind DNA ahead of the MCM helicase and obstruct fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061).
Gene Information
| Human | |
|---|---|
| Gene Name: | SLFN11 |
| Uniprot: | Q7Z7L1 |
| Entrez: | 91607 |
Family
| Belongs to: |
|---|
| Schlafen family |
Alternative Names
FLJ34922; schlafen family member 11
Molecular Weight
Mass (kDA):
102.836 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (35350305..35373914, complement) |
Tissue Specificity
Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
Subcellular Localizations
Nucleus. Chromosome. Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061).
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Adenocarcinoma
- Fracture Of First Cervical Vertebra
- Melanoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
- Immunologic Deficiency Syndromes
- Virus Diseases
Pathways
- Cell Cycle
- Reverse Transcription
- Translation
- Cell Death
- Innate Immune Response
- Immune Response
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLFN11
bosterbio.com/bosterbio-gene-info-cards/SLFN11
References
PMID: 20956525 by Katsoulidis E., et al. Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells.
PMID: 23000900 by Li M., et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11.