Smoothened homolog (SMO)

G protein-coupled receptor which probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is considered to prevent normal inhibition by patched of smoothened (SMO).

Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary idea for GLI2 activation (By similarity).