Smoothened homolog Antibodies

Smoothened homolog (SMO)

G protein-coupled receptor which probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is considered to prevent normal inhibition by patched of smoothened (SMO).

Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary idea for GLI2 activation (By similarity).

Gene Information

Human
Gene Name:	SMO
Uniprot:	Q99835
Entrez:	6608

Family

Belongs to:
G-protein coupled receptor Fz/Smo family

Alternative Names

bnb; CRJS; FZD11; Gx; Protein Gx; SMO; SMOH; SMOHseven transmembrane helix receptor; smoothened (Drosophila) homolog; smoothened homolog (Drosophila); smoothened homolog; Smoothened

Molecular Weight

Mass (kDA):
86.397 kDA

Genomic Context

Human
Location:	7q32.1
Sequence:	7; NC_000007.14 (129188633..129213548)

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cell projection, cilium.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Basal Cell Carcinoma
• Cell Transformation, Neoplastic
• Medulloblastoma
• Skin Neoplasms
• Carcinogenesis
• Malignant Neoplasm Of Pancreas
• Malignant Paraganglionic Neoplasm
• Basal Cell Nevus Syndrome
• Neoplasm Metastasis

• Pancreatic Neoplasm
• Adenocarcinoma
• Nervousness
• Cerebellar Neoplasms
• Leukemia
• Brain Neoplasms
• Colorectal Cancer

Pathways

• Cell Proliferation
• Localization
• Cell Growth
• Transport
• Pathogenesis
• Cell Death
• Cell Cycle
• Regeneration
• Intraflagellar Transport
• Cell Differentiation
• Neurogenesis
• Angiogenesis
• Secretion

• Cell Migration
• Osteoblast Differentiation
• Tissue Homeostasis
• Tissue Regeneration
• Drug Resistance
• Oncogenesis
• Polyamine Homeostasis

PTMs

• Phosphorylation
• Oxidation
• Acetylation
• Cleavage
• Methylation

• Ubiquitination
• Demethylation
• Dephosphorylation
• Reduction
• Ribosylation

• Myristoylation

Research Areas

• GPCR
• Growth and Development
• Neuronal Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMO

Boster Bio: Best Uses Of The SMO Marker

This article covers the benefits and historical background of the Boster Bio: Best Uses Of The IRDN Monoclonal Antibody, as well as troubleshooting. The benefits of this marker are extensive and apply to scientists from all over the world. Read on to learn more about this product and its benefits. There are many potential uses for this marker. Listed below are some of the best.

Benefits

SMO is an effective marketing technique that can improve your brand's visibility in social media sites. Through social media, you can target specific customer groups. SMO can also increase your website's popularity, which is dependent on the number of inbound links that a particular website has. These inbound links are vital for the functioning of search engines. If you're not already using SMO, you should begin to use it now.

The SMO Marker has several benefits that will allow you to maximize your chances of beating cancer. By reducing your cancer cells' expression of this marker, you can improve the quality of life for your patients. Additionally, the SMO Marker can be used to identify patients with advanced cancers. Aside from the cancer-fighting benefits, SMO is also known to improve the patient experience of chemotherapy. This is one reason why detecting cancers early can be so helpful.

IRDN monoclonal antibody

The Boster Bio IRDN monoclonals are highly validated antibodies that are produced in-house using a variety of different clones. The antibodies can be conjugated for ICC/IF, WB, and Flow Cytometry. The customer must select the conjugate during the checkout process. The SMO marker can help distinguish one molecule from another.

A monoclonal antibody has high specificity for a single epitope on an antigen, low non-specific cross-reactivity, and a relatively high reproducibility. Traditionally, monoclonal antibodies are raised in mice for various applications. However, new techniques have enabled researchers to produce monoclonal antibodies that recognize a variety of species. IRDN is a common antigen found in humans and other mammals.