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Suv39h2 Antibodies
AND Suv39h2 ELISA kits, Suv39h2 Proteins
Many biological assays use antibodies to detect Suv39h2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Suv39h2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Suv39h2 antibodies...
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Suv39h2 Infographic by Boster Bio
All Suv39h2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05361-2
100 μg/vial
Cat # A05361-2
100 μg/vial
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M05361-1
100 μl/vial
Cat # M05361-1
100 μl/vial
Suv39h2 Overview
Facts about Histone-lysine N-methyltransferase SUV39H2.
Histone-lysine N-methyltransferase SUV39H2 (Suv39h2)
Histone methyltransferase that especially trimethylates'Lys-9' of histone H3 using monomethylated H3'Lys- 9' as substrate. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.
H3'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in several processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Suv39h2 |
| Uniprot: | Q9EQQ0 |
| Entrez: | 64707 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
FLJ23414Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; histone-lysine N-methyltransferase SUV39H2; KMT1BEC 2.1.1.43; Lysine N-methyltransferase 1B; Su(var)3-9 homolog 2; suppressor of variegation 3-9 homolog 2 (Drosophila); Suppressor of variegation 3-9 homolog 2
Molecular Weight
Mass (kDA):
54.098 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2 A1|2 1.95 cM |
| Sequence: | 2; |
Tissue Specificity
Testis specific; predominant expression in type B spermatogonia and preleptotene spermatocytes.
Diseases
- Malignant Neoplasms
- Carcinoma
- Lung Neoplasms
- Leukemia
- Malignant Neoplasm Of Lung
- Neoplasms
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Stomach Neoplasms
- Mutation, Out-of-frame
- Diabetic Nephropathy
- Malignant Neoplasm Of Breast
Pathways
- Methylation
- Dna Methylation
- Regulation Of Gene Expression
- Histone Modification
- Demethylation
- Histone Methylation
- Cell Proliferation
- Response To Stress
- Cell Development
- Localization
- Spermatogenesis
- Histone H3 Acetylation
PTMs
- Methylation
- Acetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Suv39h2
bosterbio.com/bosterbio-gene-info-cards/Suv39h2
References
PMID: 11094092 by O'Carroll D., et al. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression.
PMID: 11701123 by Peters A.H.F.M., et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.