Histone-lysine N-methyltransferase SUV39H2 (Suv39h2)

Histone methyltransferase that especially trimethylates'Lys-9' of histone H3 using monomethylated H3'Lys- 9' as substrate. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

H3'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in several processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length.