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This action allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes such as IFNA and IFNB. So as to establish this antiviral state, TBK1 form several diverse complexes whose composition is dependent upon the type of cell and cellular stimuli.
|protein kinase superfamily|
|Sequence:||12; NC_000012.12 (64452105..64502114)|
Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina.
Cytoplasm. Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2.