Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP)

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune reaction. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response.

Positively regulates the production of TNF-alpha and interleukin-6. .