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- Table of Contents
TIRAP Antibodies
AND TIRAP ELISA kits, TIRAP Proteins
Many biological assays use antibodies to detect TIRAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIRAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIRAP antibodies...
Designing a Western blot for TIRAP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TIRAP Western Blot GuideTIRAP Infographic by Boster Bio
All TIRAP Products
Product
Figures
Specificity
Applications
Price
TIRAP Overview
Facts about Toll/interleukin-1 receptor domain-containing adapter protein.
Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP)
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune reaction. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response.
Positively regulates the production of TNF-alpha and interleukin-6. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TIRAP |
| Uniprot: | P58753 |
| Entrez: | 114609 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
adapter protein wyatt; Adaptor protein Wyatt; MAL; MyD88 adapter-like protein; MyD88-2; TIR domain-containing adapter protein; toll/interleukin-1 receptor domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor adaptor protein; wyatt
Molecular Weight
Mass (kDA):
23.883 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q24.2 |
| Sequence: | 11; NC_000011.10 (126283087..126294933) |
Tissue Specificity
Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Subcellular Localizations
Cytoplasm. Cell membrane. Membrane. Colocalizes with DAB2IP at the plasma membrane.
Diseases
- Inflammation
- Innate Immune Response
- Infective Disorder
- Tuberculosis
- Malaria
- Systemic Infection
- Bacterial Infections
- Inflammatory Response
- Communicable Diseases
- Malignant Neoplasms
- Tuberculosis, Pulmonary
- Meningitis
- Virus Diseases
Interacting Proteins
- AGER
- ARAF
- CASP1
- CCDC47
- IRAK1
- IRAK2
- IRAK4
- LTN1
- MYD88
- PIK3R1
Pathways
- Immune Response
- Cytokine Production
- Innate Immune Response
- Pathogenesis
- Secretion
- Inflammatory Response
- Localization
- Cell Activation
- Cell Maturation
- Macrophage Activation
- Response To Lipopolysaccharide
- Translation
- Cell Death
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Reduction
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIRAP
bosterbio.com/bosterbio-gene-info-cards/TIRAP
References
PMID: 11544529 by Fitzgerald K.A., et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
PMID: 11526399 by Horng T., et al. TIRAP: an adapter molecule in the Toll signaling pathway.
1 Publications of Boster TIRAP Antibodies & ELISA Kits
- PubMed ID: 32417325, Wang F,Ji S,Wang M,Liu L,Li Q,Jiang F,Cen J,Ji B.HMGB1 promoted P-glycoprotein a...
*More publications can be found for each product on its corresponding product page