TNIK Antibodies

AND TNIK ELISA kits, TNIK Proteins

Many biological assays use antibodies to detect TNIK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNIK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNIK antibodies...

We validate the specificity of these antibodies to TNIK by testing them on tissues known to express TNIK positively and negatively. Browse below to find the TNIK antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNIK Infographic by Boster Bio

All TNIK Products

Product

Figures

Specificity

Applications

Price

Anti-TNIK Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03934
100ul

TNIK (NM_015028) Human Over-expression Lysate

Human

$960
Cat # LS023043
100 µg

Anti-TNIK Antibody Picoband™

+12

Human, Mouse

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03934-3
100 µg/vial

TNIK Overview

Facts about TRAF2 and NCK-interacting protein kinase.

TNIK 3D structure. Source: alphafold

TRAF2 and NCK-interacting protein kinase (TNIK)

Serine/threonine kinase that serves as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression.

Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.

Gene Information

Human
Gene Name:	TNIK
Uniprot:	Q9UKE5
Entrez:	23043

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; KIAA0551EC 2.7.11.1; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase

Molecular Weight

Mass (kDA):
154.943 kDA

Genomic Context


Human

Location:	3q26.2-q26.31
Sequence:	3; NC_000003.12 (171058414..171460408, complement)

Tissue Specificity

Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.

Subcellular Localizations

Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Diseases

Malignant Neoplasms
Schizophrenia
Colorectal Cancer
Mental Disorders
Bipolar Disorder
Tissue Adhesions
Colorectal Neoplasms
Malignant Tumor Of Colon
Neoplasms
Anxiety Disorders
Autistic Disorder
Malnutrition
Malignant Neoplasm Of Breast

Trinucleotide Repeat Expansion
Myeloid Leukemia, Chronic
Carcinogenesis
Carcinoma
Immunologic Deficiency Syndromes
Fibrosarcoma
Multiple Myeloma

Interacting Proteins

CTNNB1
DISC1
IKBKB
MAP3K7
TAB2

Tanc1
TCF7L2
TRAF2
TRAF6

Pathways

Cell Adhesion
Localization
Brain Development
Transport
Cell Proliferation
Response To Stress
Convergent Extension
Camp-mediated Signaling
Regulation Of Cytoskeleton
Immune Response
Synaptic Transmission
Endosome Localization

Protein Transport
Myelination
Intracellular Protein Transport
Cell Motility
Cell Growth
Forebrain Development
Cell-cell Adhesion

PTMs

Phosphorylation
Farnesylation
Cleavage

Geranylgeranylation
Palmitoylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNIK

References

PMID: 10521462 by Fu C.A., et al. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.

PMID: 15342639 by Taira K., et al. The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.