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- Table of Contents
Facts about TRAF2 and NCK-interacting protein kinase.
Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.
Human | |
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Gene Name: | TNIK |
Uniprot: | Q9UKE5 |
Entrez: | 23043 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; KIAA0551EC 2.7.11.1; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase
Mass (kDA):
154.943 kDA
Human | |
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Location: | 3q26.2-q26.31 |
Sequence: | 3; NC_000003.12 (171058414..171460408, complement) |
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
PMID: 10521462 by Fu C.A., et al. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.
PMID: 15342639 by Taira K., et al. The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.