TNNC1 Antibodies

Troponin C, slow skeletal and cardiac muscles (TNNC1)

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.

The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. .

Gene Information

Human
Gene Name:	TNNC1
Uniprot:	P63316
Entrez:	7134

Family

Belongs to:
troponin C family

Alternative Names

cardiac troponin C; CMD1Z; CMH13; slow twitch skeletal/cardiac muscle troponin C; TNC; TN-C; TNNC; troponin C type 1 (slow); troponin C, slow skeletal and cardiac muscles; troponin C, slow; troponin C1, slow

Molecular Weight

Mass (kDA):
18.403 kDA

Genomic Context

Human
Location:	3p21.1
Sequence:	3; NC_000003.12 (52451100..52454041, complement)

Diseases

• Cardiomyopathies
• Hypertrophy
• Hypertrophic Cardiomyopathy
• Cardiomyopathy, Familial Idiopathic
• Cardiomyopathy, Dilated
• Cardiomyopathy, Hypertrophic, Familial
• Sudden Cardiac Death
• Heart Diseases
• Cardiac Death
• Tumor Angiogenesis
• Sudden Death
• Heart Failure

• Muscle Twitch
• Pregnancy Complications
• De Novo Mutation
• Carcinoma
• Malignant Neoplasms
• Ventricular Dysfunction

Interacting Proteins

• TNNI1
• TNNI3

Pathways

• Pathogenesis
• Angiogenesis
• Transport
• Cell Adhesion
• Immune Response
• Heart Development

PTMs

• Phosphorylation

Research Areas

• Cell Biology
• Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNNC1

Boster Bio - Best Uses Of The TNNC1 Marker

This article will review the Boster Bio Anticardiac Troponin/TNNC1 Marker. We'll examine its applications and research. Boster scientists may submit their results to receive samples from other species or applications. The best thing is that it's open for all scientists worldwide. You can submit results to earn product credits.

Boster Bio Anticardiac Troponin (C/TNNC1) Marker

This antibody has been validated against Troponin C, the Human protein. This protein is encoded at chromosome 3, by the TNNC1 genes. A Genebridge4 radiation-hybrid panel detected TNNC1 in chromosome3p. Circular dichroism measurements revealed a change in secondary structure in TNNC1 mutations. There are many formats for the antibody, including Western blot and IHC.

Cardiac troponins have the ability to detect myocardial injury. Although the concentration of cardiac troponins can be used to determine myocardial injury in quantitative terms, it does not reveal the underlying mechanism. The laboratory can diagnose acute myocardial damage (AMI) using the two cardioprotective biomarkers, cardiac troponins I and T. Both markers are sensitive and specific for myocardial injury. However, the process to degrade troponins is complicated.