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- Table of Contents
TRAF3 Antibodies
AND TRAF3 ELISA kits, TRAF3 Proteins
Many biological assays use antibodies to detect TRAF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAF3 antibodies...
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TRAF3 Overview
Facts about TNF receptor-associated factor 3.
TNF receptor-associated factor 3 (TRAF3)
Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon.
Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAF3 |
| Uniprot: | Q13114 |
| Entrez: | 7187 |
Family
| Belongs to: |
|---|
| TNF receptor-associated factor family |
Alternative Names
CAP1; CAP-1CD40 receptor associated factor 1; CD40 associated protein 1; CD40 binding protein; CD40 receptor-associated factor 1; CD40-binding protein; CD40bp; CRAF1; CRAF1CAP1; LAP1; LAP1CD40BP; LMP1-associated protein 1; TNF receptor-associated factor 3; TRAF3; TRAF-3
Molecular Weight
Mass (kDA):
64.49 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.32 |
| Sequence: | 14; NC_000014.9 (102777449..102911500) |
Subcellular Localizations
Cytoplasm. Endosome. Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphoma
- Virus Diseases
- Carcinoma
- Inflammation
- B-cell Lymphomas
- Multiple Myeloma
- Innate Immune Response
- Infective Disorder
- Hodgkin Disease
- Autoimmunity
Interacting Proteins
- Azi2
- BRAF
- CD40
- EDA2R
- IP6K3
- Irf1
- LTBR
- MAP3K14
- PTPN22
- RIPK2
Pathways
- Cell Death
- Immune Response
- Localization
- Pathogenesis
- Cell Activation
- Cytokine Production
- Secretion
- B Cell Activation
- Cell Proliferation
- Type I Interferon Production
- Isotype Switching
- Innate Immune Response
- Cell Growth
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Glutathionylation
Research Areas
- Apoptosis
- Immunology
- Innate Immunity
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF3
bosterbio.com/bosterbio-gene-info-cards/TRAF3
References
PMID: 7527023 by Hu H.M., et al. A novel RING finger protein interacts with the cytoplasmic domain of CD40.
PMID: 7859281 by Mosialos G., et al. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.