TRAF3 Antibodies

TNF receptor-associated factor 3 (TRAF3)

Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon.

Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses.

Gene Information

Human
Gene Name:	TRAF3
Uniprot:	Q13114
Entrez:	7187

Family

Belongs to:
TNF receptor-associated factor family

Alternative Names

CAP1; CAP-1CD40 receptor associated factor 1; CD40 associated protein 1; CD40 binding protein; CD40 receptor-associated factor 1; CD40-binding protein; CD40bp; CRAF1; CRAF1CAP1; LAP1; LAP1CD40BP; LMP1-associated protein 1; TNF receptor-associated factor 3; TRAF3; TRAF-3

Molecular Weight

Mass (kDA):
64.49 kDA

Genomic Context

Human
Location:	14q32.32
Sequence:	14; NC_000014.9 (102777449..102911500)

Subcellular Localizations

Cytoplasm. Endosome. Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.

Diseases

• Neoplasms
• Malignant Neoplasms
• Lymphoma
• Virus Diseases
• Carcinoma
• Inflammation
• B-cell Lymphomas
• Multiple Myeloma
• Innate Immune Response
• Infective Disorder
• Hodgkin Disease
• Autoimmunity

• Autoimmune Reaction
• Autoimmune Diseases
• Malignant Paraganglionic Neoplasm
• Tissue Adhesions
• Stomatitis
• Vesicular Stomatitis
• Hypergammaglobulinemia

Interacting Proteins

• Azi2
• BRAF
• CD40
• EDA2R
• IP6K3

• Irf1
• LTBR
• MAP3K14
• PTPN22
• RIPK2

• SNAP29
• TANK
• TRAF3IP1
• TRAF5
• WDR5

• ZMYND11

Pathways

• Cell Death
• Immune Response
• Localization
• Pathogenesis
• Cell Activation
• Cytokine Production
• Secretion
• B Cell Activation
• Cell Proliferation
• Type I Interferon Production
• Isotype Switching
• Innate Immune Response
• Cell Growth

• Cell Cycle
• Cell Differentiation
• B Cell Differentiation
• T Cell Activation
• B Cell Proliferation
• Cytokine Secretion
• Virulence

PTMs

• Phosphorylation
• Ubiquitination
• Cleavage
• Glutathionylation

• Reduction
• Glycosylation
• Acetylation
• Myristoylation

Research Areas

• Apoptosis
• Immunology
• Innate Immunity
• Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF3

Boster Bio - Best Uses Of The TRAF3 Marker

Steven Boster's bio-related research projects have been the focus of his work and his work on TRAF3-based technology is one of the most remarkable. What does Boster Bio actually mean for researchers? It means that he has the equipment to analyze and present the results of his research, which is applicable to all scientists around the world. Whether you are a scientist working in the field of academia or in a company laboratory you will benefit from Boster Bio.

Primary antibodies with high-affinity

A new series of high-affinity primaries was developed using the TRAF3 marker. This marker recognizes NPs through their C-termini. It has been demonstrated to recognize TRAF3/B cells in mouse models as well as human samples. The TRAF3 mouse model shows a significant decrease in the number of B cell precursors in bone marrow.

The affinity dissociation constant (KD) is inversely proportional to the concentration of the antibody. The affinity of an antibody is proportional to its KD value. The data were processed by scientists from UC Davis. The results were reviewed and analyzed by scientists from Abcam. Utilizing the TRAF3 marker as a reference, high-affinity primary antibodies are now available.

TRAF3 is an essential part of postnatal development and the immune system. The TRAF family of proteins comprises members with distinct functions and motifs. These proteins act as adaptors and recruit additional proteins to multiprotein signaling systems. These proteins are vital for the survival of cells, their proliferation, and differentiation. There are many TRAFs within the body and you can recognize their specificity by using TRAF markers.

The TRAF3 marker can be used to determine the affinity of small resting B cell populations. It also plays a crucial part in the differentiation of B cells into plasma cells. It is also used to determine whether high-affinity antibody production has occurred in mice using the TRAF3 marker. High-affinity primary antibodies made using the TRAF3 marker are available for a broad variety of immunological applications that range from the detection of virus-related infections to the detection of antigens in the blood.

The TRAF3 gene is a vital regulator of the differentiation of B cells by an antigen. By blocking TRAF3, antibodies to TRAF can be used to detect an antigen with a specificity. For this purpose high-affinity primary antibodies that target the TRAF3 gene are commonly used for immunotherapy. However, these antibodies might not be appropriate to be used in all situations. It is essential to comprehend the role of TRAF to ensure you choose the most effective antibody.

High-affinity TRAF3 marker

When choosing the right antibody for TRAF3 analysis, it is important to choose a product that offers high affinity for the protein you want to target. Boster antibodies are highly cited and trusted by researchers and are tested in Western Blotting, Immunohistochemistry, and ELISA. Here are some high-affinity TRAF3 markers. Continue reading to learn more about these proteins. Listed below are some of Boster's high-affinity TRAF3 markers.

Boster Bio High-affinity TRAF2/3 markers have been created using mice that have been genetically altered to express mutations within the TRAF2/3 genes. These mice have defects in the process of CD40-mediated isotype switching proliferative, and activation NFkb and JNK. Since CD40 is a crucial transcription factor for the formation and activation of B cells, this marker can detect mutations in the TRAF2/3 gene.

Steven Boster's life story

Don "Steve" Boster, aged 59, passed away on June 6 2022. He was born in Joliet (Illinois). He was a retired sales manager for many years and was a member of Concordia Hall in Staunton, VA. Steve is survived by his wife, Susan, two daughters, Crystal Boster and Natosha Peck and six grandchildren, four brothers and four sisters, including Jack Boster and Sandra Blanton. He is also survived by a number of nieces and nephews.

Boster's love for gospel southern music and a passion for sports led him to create a multitude of primary antibodies. He became the largest antibody catalog company in China in the late nineties. Boster's expertise in the field of developing ELISAs and other immunoassays inspired him to develop a proprietary ELISA platform, dubbed PicoKine(tm). The kits provide unbeatable accuracy and sensitivity. Steven Boster's history includes several lawsuits and numerous patents.