TRPC5 Antibodies

Short transient receptor potential channel 5 (TRPC5)

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

Gene Information

Human
Gene Name:	TRPC5
Uniprot:	Q9UL62
Entrez:	7224

Family

Belongs to:
transient receptor (TC 1.A.4) family

Alternative Names

hTRP5; hTRP-5; short transient receptor potential channel 5; transient receptor potential cation channel, subfamily C, member 5; Transient receptor protein 5; TRP-5; TRP5transient receptor potential channel 5; TrpC5

Molecular Weight

Mass (kDA):
111.412 kDA

Genomic Context

Human
Location:	Xq23
Sequence:	X; NC_000023.11 (111774314..112082943, complement)

Tissue Specificity

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

• Hypertensive Disease
• Nervousness
• Hypoxia
• Asthma
• Columnar Cell Hyperplasia Of The Breast
• Pain
• Diabetes Mellitus
• Inflammation
• Pertussis
• Pathologic Vasoconstriction
• Hypertrophy
• Atherosclerosis

• Acidosis
• Neoplasms
• Cardiovascular Diseases
• Ischemia
• Diabetes Mellitus, Non-insulin-dependent
• Autoimmune Reaction
• Essential Hypertension

Pathways

• Localization
• Secretion
• Cell Proliferation
• Store-operated Calcium Entry
• Rna Interference
• Transport
• Cell Migration
• Vasoconstriction
• Synaptic Transmission
• Cell Differentiation
• Gene Silencing
• Neuroprotection
• Cell Activation

• Catecholamine Secretion
• Cell Motility
• Lactation
• Cellular Localization
• Muscle Contraction
• Membrane Depolarization
• Cell Death

PTMs

• Phosphorylation
• Biotinylation

• Cleavage
• Nitrosylation

• Hydroxylation

Research Areas

• Breast Cancer
• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPC5

Best Uses Of The TRPC5 Marker

As a scientist, you may wonder if there's a way to validate a PCR product using the TRPC5 marker. If so, this article will address that question. In addition, it will address the validity of the TRPC5 marker, as well as the uses of lead indications. In addition, we'll discuss the role of investors in this process.

Anti-TRPC5 Marker

The Anti-TRPC5 Marker in Boston Bio is a protein that is restricted to the odontoblast cell layer. The protein is important for the regulation of calcium channel activity. This is a necessary and relevant protein for inflammatory tooth pain. Its presence in the body also makes it a vital marker for inflammatory tooth pain. Nevertheless, there are some problems associated with the use of TRPC5 in diagnostic tests.

The function of TRPC5 in arthritic pain is uncertain. While it plays a crucial role in pain signalling and inflammatory processes, research has yet to pinpoint how this protein may influence disease progression. In mice with OA, the TRPC5-deficient condition leads to increased expression of extracellular remodelling enzymes and exacerbated pain-related behaviour. In addition, anti-TRPC5 is linked to the regulation of Akt/IkB/NF-kB signalling pathways, which are implicated in the progression of OA.

Boster Bio has validated its Anti-TRPC5 Marker by using known positive and negative samples to demonstrate its high affinity and specificity. Boster rewards the first reviewer of its products with product credits. In return, scientists from all over the world are rewarded with product credits for submitting the first review. It is a way of rewarding scientists who have contributed to the field. So, what are you waiting for? Go ahead and order your Anti-TRPC5 Marker today!

AC1903 has been shown to protect podocyte foot processes from effacement. Thus, it is important to understand how TRPC5 channels function in podocyte injury. To understand the role of TRPC5 in podocyte injury by PAN, AC1903 has been shown to be an important therapeutic agent. Therefore, the Anti-TRPC5 Marker in Boster Bio should be the first choice of any scientist looking to perform a functional analysis of the podocyte foot process.

In addition to this marker, there is an Anti-TRPC4 and Anti-TRPC5 agonist. Anti-TRPC5 is a highly sensitive and specific antibody to detect the presence of TRPC5 in human podocytes. However, it is worth noting that AC1903 has a low affinity for TRPC4 and TRPC5 in humans. These antibodies are available in many different formats, including Boster Bio.

Validation

A recent study has validated a marker for the presence of the TRPC5 gene in colon cancer by imaging tumors in living people. In this study, the TRPC5 gene is expressed in colon cancer cells through an induction of EMT through the HIF-1a signaling pathway. During this incubation, TRPC5 mRNA abundance increased by twofold in comparison to control cells. In addition, the expression of the TRPC5 gene was significantly increased in endothelial cells, as compared to controls.

The overexpression of TRPC5 in vivo may have a role in kidney filtration. The researchers assessed albuminuria in TG, DN, and B/6 mice, and found that it was low in all groups at month 2 and month 8. Histologic analysis did not show any morphologic changes at the glomerulus level in all groups. Thus, the overexpression of TRPC5 in mice does not lead to disease progression in humans.

Further, in transgenic mouse models, TRPC5 expression was confirmed. The level of expression was eight to ten fold higher in TG and DN mice. qPCR products were then analyzed, and the results indicated that one band was corresponding to the level of expression in each sample. Interestingly, there was no significant differential expression of TRPC5 in TRPCs 1-4. Further, this marker is highly specific in its detection in vivo.

However, the evidence for a TRPC5 gene-based diagnosis of glomerular disease remains limited. Although overexpression of TRPC5 in mice did not lead to proteinuria or glomerular injury, it did impair podocyte function. Further studies are required to identify the integrated role of the TRPC family of channels in podocyte biology. But the initial data are encouraging. And this study highlights the potential of the TRPC5 gene for therapeutic intervention.

Lead Indications

When it comes to researching the TRPC5 gene, there are few antibodies as effective and highly cited as those made by Boster. Boster offers highly specific primary antibodies that are validated in Western blotting, Immunohistochemistry, and ELISA. The high affinity and specificity of Boster antibodies are the reason for their widespread use in research. The company also offers a comprehensive library of over 250 gene therapy antibodies.

Investors

While investors may be interested in the TRPC5 marker, the data behind it are mixed. These results are based on concentration-response data. In contrast, the TRPC5 marker was able to generate positive returns in the past, and the company's shares have recently increased in value. Although the TRPC5 marker may have an unfavorable history in the market, the company's recent performance indicates that it is likely to continue to grow.