This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Tet3 Antibodies
AND Tet3 ELISA kits, Tet3 Proteins
Many biological assays use antibodies to detect Tet3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tet3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tet3 antibodies...
Designing a Western blot for Tet3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TET3 Western Blot GuideDesigning an IHC experiment for Tet3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TET3 IHC GuideTet3 Infographic by Boster Bio
All Tet3 Products
Product
Figures
Specificity
Applications
Price
Tet3 Overview
Facts about Methylcytosine dioxygenase TET3.
Methylcytosine dioxygenase TET3 (Tet3)
Dioxygenase that catalyzes the conversion of the modified genomic foundation 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming from the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC into 5-carboxylcytosine (5caC).
Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and leads to modulate the expression of numerous developmental genes.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Tet3 |
| Uniprot: | Q8BG87 |
| Entrez: | 194388 |
Family
| Belongs to: |
|---|
| TET family |
Alternative Names
EC 1.14.11.n2; hCG_40738; KIAA0401; methylcytosine dioxygenase TET3; MGC22014; probable methylcytosine dioxygenase TET3; tet oncogene family member 3
Molecular Weight
Mass (kDA):
194.792 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6|6 C3 |
| Sequence: | 6; |
Tissue Specificity
Highly expressed in oocytes and zygotes. Not expressed in embryonic stem cells (ES cells).
Diseases
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Myelomonocytic Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Neoplasms
- Leukemia
- Leukemia, Myelomonocytic, Chronic
- Reperfusion Injury
- Ischemia
- Colonic Neoplasms
- Schizophrenia
Pathways
- Demethylation
- Methylation
- Dna Demethylation
- Dna Methylation
- Fertilization
- Cell Activation
- Cell Cycle Checkpoint
- Aging
- Mitosis
- T Cell Activation
- Localization
- Embryo Development
- Response To Oxidative Stress
PTMs
- Demethylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tet3
bosterbio.com/bosterbio-gene-info-cards/Tet3
References
PMID: 23217707 by Xu Y., et al. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.
PMID: 23690950 by Liu N., et al. Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules.