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- Table of Contents
USP15 Antibodies
AND USP15 ELISA kits, USP15 Proteins
Many biological assays use antibodies to detect USP15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP15 antibodies...
Designing a Western blot for USP15? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the USP15 Western Blot GuideUSP15 Infographic by Boster Bio
All USP15 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A03060-3
100 μg/vial
Cat # A03060-3
100 μg/vial
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03057-1
100 μg/vial
Cat # A03057-1
100 μg/vial
USP15 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 15.
Ubiquitin carboxyl-terminal hydrolase 15 (USP15)
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the exact mechanism is still unclear: according to a report, acts by encouraging deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and encouraging activation of TGF- beta target genes (PubMed:21947082).
According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates and'Lys- 48'-linked polyubiquitin chains, protecting them against proteasomal degradation.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP15 |
| Uniprot: | Q9Y4E8 |
| Entrez: | 9958 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 15; EC 3.1.2.15; EC 3.4.19.12; Gcap18; KIAA0529; KIAA0529ubiquitin carboxyl-terminal hydrolase 15; MGC131982; MGC149838; MGC74854; ubiquitin specific peptidase 15; ubiquitin specific protease 15; ubiquitin thioesterase 15; Ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; Ubp109; UNPH-2; UNPH4; USP15
Molecular Weight
Mass (kDA):
112.419 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q14.1 |
| Sequence: | 12; NC_000012.12 (62260340..62416389) |
Tissue Specificity
Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
Subcellular Localizations
Cytoplasm. Nucleus. Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Ovary
- Adenomatous Polyposis Coli
- Polyposis
- Hyperplasia
- Stomach Neoplasms
- Neoplasm Metastasis
- Von Hippel-lindau Syndrome
- Myopathy
- Cardiovascular Diseases
- Tumor Angiogenesis
- Mammary Neoplasms
Interacting Proteins
- CARD9
- CCDC57
- INCA1
- MAD1L1
- SPDL1
- TRIM21
- URM1
Pathways
- Proteolysis
- Pathogenesis
- Localization
- Drug Resistance
- Notch Signaling Pathway
- Mitosis
- Angiogenesis
- Nuclear Export
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP15
bosterbio.com/bosterbio-gene-info-cards/USP15
References
PMID: 10444327 by Baker R.T., et al. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases.
PMID: 12532266 by Angelats C., et al. Isolation and characterization of the mouse ubiquitin-specific protease Usp15.