XIAP Antibodies

E3 ubiquitin-protein ligase XIAP (XIAP)

Multi-functional protein which modulates not just caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, in addition to cell invasion and metastasis. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry.

Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin.

Gene Information

Human
Gene Name:	XIAP
Uniprot:	P98170
Entrez:	331

Family

Belongs to:
IAP family

Alternative Names

API3X-linked inhibitor of apoptosis protein; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; BIRC4; BIRC4XLP2; E3 ubiquitin-protein ligase XIAP; EC 6.3.2.-; hIAP3; hIAP-3; hILP; IAP3; IAP-3; IAP-like protein; ILP; ILP1; Inhibitor of apoptosis protein 3; MIHA; XIAP; X-linked IAP; X-linked inhibitor of apoptosis

Molecular Weight

Mass (kDA):
56.685 kDA

Genomic Context

Human
Location:	Xq25
Sequence:	X; NC_000023.11 (123859708..123913972)

Tissue Specificity

Ubiquitous, except peripheral blood leukocytes.

Subcellular Localizations

Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.

Diseases

• Malignant Neoplasms
• Neoplasms
• Leukemia
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Myeloid Leukemia
• Malignant Neoplasm Of Breast
• Lymphoma
• Malignant Neoplasm Of Prostate
• Liver Carcinoma
• Neoplasm Metastasis
• Prostatic Neoplasms

• Malignant Tumor Of Colon
• Ovarian Neoplasm
• Leukemia, Myelocytic, Acute
• Mammary Neoplasms
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Lung
• Adenocarcinoma

Interacting Proteins

• CASP10
• CASP3
• CASP7
• CASP9
• CKS1B

• DIABLO
• ERCC3
• HTRA2
• Htra2
• LONRF1

• NEK6
• NOTCH1
• PPIH
• RAC1
• RFC5

• RIPK2
• RIPK4
• SIAH1
• SSX2IP
• TRAF6

• UBC
• UBE2D1
• UBE2D2
• UBE2D3
• UBE2N

• UBE2V1
• VPS37C
• WDYHV1

Pathways

• Cell Death
• Induction Of Apoptosis
• Cell Cycle
• Cell Proliferation
• Cell Growth
• Sensitization
• Programmed Cell Death
• Cell Cycle Arrest
• Rna Interference
• Pathogenesis
• Translation
• Drug Resistance
• Angiogenesis

• Localization
• Cell Killing
• Gene Silencing
• Secretion
• Neuroprotection
• Cell Migration
• Proteolysis

PTMs

• Cleavage
• Phosphorylation
• Ubiquitination
• Dephosphorylation
• Acetylation
• Methylation
• Reduction
• Demethylation

• Sumoylation
• Nitrosylation
• Phosphorothioation
• Prenylation
• Deacetylation
• Acylation
• Glycosylation
• Oxidation

Research Areas

• Apoptosis
• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XIAP

Best Uses Of The XIAP Marker

This article will discuss XIAP and its expression in different tissues, including BMSCs, brain tissues, and astrocytes. It will also discuss the inhibitory effect of XIAP on apoptosis. In addition, you'll learn how to use Boster Bio as part of your research. In addition, you'll discover how Boster Bio is used in a variety of other areas, including metabolomics, cell biology, and pharmacology.

XIAP expression in BMSCs

XIAP expression in BMSC can alleviate CP in rats with cerebral ischemia. In this study, adenovirus-mediated XIAP modification of BMSCs was used to treat rats with cerebral ischemia. The effects of XIAP-modified BMSCs on brain injury were also evaluated in CP rats. However, more research is needed to determine the functional role of XIAP in brain injury.

In addition, XIAP interacts with STX17, which regulates autophagosome-lysosome fusion in senescent cells. XIAP expression in BMSCs is not affected by AT-406 treatment alone. This suggests that XIAP plays a role in determining cell viability, but the relationship between autophagy and apoptosis is still unclear.

In the present study, XIAP was expressed in BMSCs after the inoculation of recombinant adenoviral vectors expressing XIAP. The expression of XIAP mRNA in BMSCs was examined by using Ad-GFP in adenoviral vector-transfected BMSCs. The resulting xIAP-expressing cells showed significantly shorter slope test times than those of uninfected BMSCs.

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