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- Table of Contents
XIAP Antibodies
AND XIAP ELISA kits, XIAP Proteins
Many biological assays use antibodies to detect XIAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with XIAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop XIAP antibodies...
Designing a Western blot for XIAP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the XIAP Western Blot GuideXIAP Infographic by Boster Bio
All XIAP Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # PA1218
100 μg/vial
Cat # PA1218
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M00482-2
20μL, 40μL, 100μL, 200μL
Cat # M00482-2
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1601
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1601
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2499
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2499
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2498
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2498
1 kit, containing two 96-well plates and all necessary reagents
XIAP Overview
Facts about E3 ubiquitin-protein ligase XIAP.
E3 ubiquitin-protein ligase XIAP (XIAP)
Multi-functional protein which modulates not just caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, in addition to cell invasion and metastasis. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry.
Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin.
Gene Information
| Human | |
|---|---|
| Gene Name: | XIAP |
| Uniprot: | P98170 |
| Entrez: | 331 |
Family
| Belongs to: |
|---|
| IAP family |
Alternative Names
API3X-linked inhibitor of apoptosis protein; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; BIRC4; BIRC4XLP2; E3 ubiquitin-protein ligase XIAP; EC 6.3.2.-; hIAP3; hIAP-3; hILP; IAP3; IAP-3; IAP-like protein; ILP; ILP1; Inhibitor of apoptosis protein 3; MIHA; XIAP; X-linked IAP; X-linked inhibitor of apoptosis
Molecular Weight
Mass (kDA):
56.685 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq25 |
| Sequence: | X; NC_000023.11 (123859708..123913972) |
Tissue Specificity
Ubiquitous, except peripheral blood leukocytes.
Subcellular Localizations
Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Myeloid Leukemia
- Malignant Neoplasm Of Breast
- Lymphoma
- Malignant Neoplasm Of Prostate
- Liver Carcinoma
- Neoplasm Metastasis
- Prostatic Neoplasms
Interacting Proteins
- CASP10
- CASP3
- CASP7
- CASP9
- CKS1B
- DIABLO
- ERCC3
- HTRA2
- Htra2
- LONRF1
Pathways
- Cell Death
- Induction Of Apoptosis
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Sensitization
- Programmed Cell Death
- Cell Cycle Arrest
- Rna Interference
- Pathogenesis
- Translation
- Drug Resistance
- Angiogenesis
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Acetylation
- Methylation
- Reduction
- Demethylation
Research Areas
- Apoptosis
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XIAP
bosterbio.com/bosterbio-gene-info-cards/XIAP
References
PMID: 8654366 by Duckett C.S., et al. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
PMID: 8552191 by Liston P., et al. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
5 Publications of Boster XIAP Antibodies & ELISA Kits
- PubMed ID: 34045807, Tutuncu EO,Dundar ZD,Kilinc I,Tutuncu A,Kocak S,Girisgin AS.Prognostic Value of ...
- PubMed ID: 28300775, Wei H, Gao Z, Zheng L, Zhang C, Liu Z, Yang Y, Teng H, Hou L, Yin Y, Zou X0. Mar...
- PubMed ID: 25878591, Chen Gg, Mao M, Qiu Lz, Liu Qm. Neural Regen Res. 2015 Mar;10(3):425-31. Doi: 10...
- PubMed ID: 23391179, Wu L, Xi Z, Guo R, Liu S, Yang S, Liu D, Dong S, Guo D. Avian Pathol. 2013 Feb;4...
- PubMed ID: 23611778, Li G, Zhang S, Fang H, Yan B, Zhao Y, Feng L, Ma X, Ye X. Biochem Biophys Res Co...
*More publications can be found for each product on its corresponding product page