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- Table of Contents
YME1L1 Antibodies
AND YME1L1 ELISA kits, YME1L1 Proteins
Many biological assays use antibodies to detect YME1L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with YME1L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop YME1L1 antibodies...
Designing an IHC experiment for YME1L1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the YME1L1 IHC GuideYME1L1 Infographic by Boster Bio
All YME1L1 Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS010730
20 µg, 100 µg
Cat # LS010730
20 µg, 100 µg
YME1L1 Overview
Facts about ATP-dependent zinc metalloprotease YME1L1.
ATP-dependent zinc metalloprotease YME1L1 (YME1L1)
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane area (PubMed:26923599, PubMed:27786171). Plays an essential role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975).
Ensures cell proliferation, keeps normal cristae morphology and complicated I respiration activity, promotes antiapoptotic action and protects mitochondria in the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975).
Gene Information
| Human | |
|---|---|
| Gene Name: | YME1L1 |
| Uniprot: | Q96TA2 |
| Entrez: | 10730 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ATP-dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease FtsH1; ATP-dependent metalloprotease YME1L1; EC 3.4.24; EC 3.4.24.-; FTSH; FTSH1; MEG4; Meg-4; PAMPATP-dependent zinc metalloprotease YME1L1; Presenilin-associated metalloprotease; YME1 (S.cerevisiae)-like 1; YME1-like 1 (S. cerevisiae); YME1-like protein 1; YME1Lmeg-4
Molecular Weight
Mass (kDA):
86.455 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p12.1 |
| Sequence: | 10; NC_000010.11 (27110111..27155051, complement) |
Tissue Specificity
High expression in cardiac and skeletal muscle mitochondria.
Subcellular Localizations
Mitochondrion inner membrane. Mitochondrion.
Diseases
- Aortic Aneurysm, Abdominal
- Paraplegia
- Spastic Paraplegia
- Optic Atrophy
- Fracture Of First Cervical Vertebra
- Neurodegenerative Disorders
- Mitochondrial Diseases
- Spastic Paraplegia, Hereditary
- Glioblastoma
- Glioma
- Atrophy
Pathways
- Oxidative Phosphorylation
- Cell Proliferation
- Mitochondrial Unfolded Protein Response
- Proteolysis
- Membrane Fusion
- Glycolysis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YME1L1
bosterbio.com/bosterbio-gene-info-cards/YME1L1
References
PMID: 10843804 by Coppola M., et al. Identification and characterization of YME1L1, a novel paraplegin- related gene.
PMID: 18076378 by Guillery O., et al. Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential.