ATP-dependent zinc metalloprotease YME1L1 (YME1L1)

ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane area (PubMed:26923599, PubMed:27786171). Plays an essential role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975).

Ensures cell proliferation, keeps normal cristae morphology and complicated I respiration activity, promotes antiapoptotic action and protects mitochondria in the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975).