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- Table of Contents
YTHDC1 Antibodies
AND YTHDC1 ELISA kits, YTHDC1 Proteins
Many biological assays use antibodies to detect YTHDC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with YTHDC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop YTHDC1 antibodies...
Designing a Western blot for YTHDC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the YTHDC1 Western Blot GuideYTHDC1 Infographic by Boster Bio
All YTHDC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A06172-1
100 μg/vial
Cat # A06172-1
100 μg/vial
YTHDC1 Overview
Facts about YTH domain-containing protein 1.
YTH domain-containing protein 1 (YTHDC1)
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and a few non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and equilibrium (PubMed:26318451, PubMed:25242552).
Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, resulting in exon-inclusion during alternative splicing (PubMed:26876937).
Gene Information
| Human | |
|---|---|
| Gene Name: | YTHDC1 |
| Uniprot: | Q96MU7 |
| Entrez: | 91746 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
YTH domain-containing protein 1
Molecular Weight
Mass (kDA):
84.7 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q13.2 |
| Sequence: | 4; NC_000004.12 (68310387..68350093, complement) |
Subcellular Localizations
Nucleus. Nucleus speckle. Localizes to a novel subnuclear structure, the YT bodies.
Interacting Proteins
- CLK2
- DVL3
- HNRNPK
- KHDRBS2
- KHDRBS3
- RBMY1F
- SDCBP2
- SRPK1
- SRPK2
- TRA2B
PTMs
- Isopeptide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YTHDC1
bosterbio.com/bosterbio-gene-info-cards/YTHDC1
References
PMID: 12755701 by Wilkinson F.L., et al. Emerin interacts in vitro with the splicing-associated factor, YT521- B.
PMID: 19282290 by Heinrich B., et al. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.