YTH domain-containing protein 1 (YTHDC1)

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and a few non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and equilibrium (PubMed:26318451, PubMed:25242552).

Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, resulting in exon-inclusion during alternative splicing (PubMed:26876937).