Zinc finger FYVE domain-containing protein 9 (ZFYVE9)

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and regulating the transcriptional activity of the SMAD3/SMAD4 complex.

Possibly connected with TGF-beta receptor internalization. .