Crohn's Disease antibodies

and ELISA kits, proteins related to Crohn's Disease.

Introduction to Crohn's Disease

Crohn's Disease is a chronic inflammatory condition that affects the gastrointestinal tract, classified under inflammatory bowel diseases (IBD). It can target any part from the mouth to the anus, but most commonly impacts the end of the small intestine and the beginning of the large intestine. Characterized by symptoms such as abdominal pain, persistent diarrhea, fatigue, and weight loss, Crohn's Disease significantly impacts patients' quality of life. The exact cause remains unclear, though it is believed to result from a combination of genetic, immune, and environmental factors. Current research is increasingly focused on the role of antibodies in the disease’s progression and management. By exploring antibody-related mechanisms, scientists aim to develop more effective, targeted therapies that can better control inflammation and induce long-term remission, offering renewed hope for those affected by Crohn's Disease.

Crohn's Disease biomarkers

PA1484

Anti-Toll-like receptor 4 TLR4 Antibody Picoband®, OTA promotes liver inflammation. a Relative mRNA expressions of TLR4, MYD88, IKBα, IL-6, and TNF-α in the liver after OTA oral gavage ( n =�...

A00526-3

Anti-ATG16L1 Antibody Picoband®, IF analysis of ATG16L1 using anti-ATG16L1 antibody (A00526-3).
ATG16L1 was detected in an immunocytochemical section of A431 cells. E...

A00249-1

Anti-C Reactive Protein/Crp Antibody Picoband®, IHC analysis of Crp using anti-Crp antibody (A00249-1).
Crp was detected in paraffin-embedded section of rat kidney ...

Protein Name	Gene Name	Function
C-reactive protein (CRP)	CRP	Acute-phase protein, marker of systemic inflammation
Tumor Necrosis Factor-alpha (TNF-α)	TNF	Pro-inflammatory cytokine involved in systemic inflammation
NOD2/CARD15	NOD2	Involved in bacterial recognition and innate immunity
Interleukin-23 Receptor (IL23R)	IL23R	Plays role in inflammatory pathways via the IL-23/Th17 axis
Autophagy-related 16 like 1 (ATG16L1)	ATG16L1	Autophagy-related, involved in handling intracellular bacteria
Immunity-Related GTPase M (IRGM)	IRGM	Autophagy and innate immunity
Matrix Metalloproteinase-9 (MMP-9)	MMP9	Involved in extracellular matrix remodeling
CD14	CD14	Co-receptor for recognition of bacterial lipopolysaccharides
Interleukin-1 beta (IL-1β)	IL1B	Pro-inflammatory cytokine
Interleukin-6 (IL-6)	IL6	Pro-inflammatory cytokine
Interleukin-10 (IL-10)	IL10	Anti-inflammatory cytokine
Toll-like receptor 4 (TLR4)	TLR4	Important for innate immune response
Interferon-gamma (IFN-γ)	IFNG	Pro-inflammatory cytokine, activates macrophages
HLA-DRB1	HLA-DRB1	MHC class II molecule involved in immune response
Janus Kinase 2 (JAK2)	JAK2	Tyrosine kinase involved in cytokine signaling
Vitamin D Receptor (VDR)	VDR	Mediates effects of vitamin D on immune system
Interleukin-17A (IL-17A)	IL17A	Pro-inflammatory cytokine involved in Th17 responses

Important Mechanisms

Immune System Dysregulation

Immune system dysregulation is a critical area of research in Crohn's Disease, focusing on understanding how the body’s immune responses contribute to chronic intestinal inflammation. In individuals with Crohn's, the immune system erroneously targets the gastrointestinal tract, leading to persistent inflammation and tissue damage. Researchers investigate the roles of various immune cells, including T cells, macrophages, and dendritic cells, and the signaling pathways that become overactive or impaired. Key cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukins, are studied for their involvement in promoting inflammatory responses. Understanding these immune mechanisms is essential for developing targeted therapies that can modulate the immune system, reduce inflammation, and induce remission. Advances in this area have led to the development of biologic drugs that specifically target immune mediators, offering more effective and personalized treatment options for patients with Crohn's Disease.

Gut Microbiome Alterations

The gut microbiome, comprising trillions of microorganisms residing in the gastrointestinal tract, plays a pivotal role in maintaining intestinal health and immune function. Research in this sub area explores how alterations in the composition and diversity of the gut microbiota contribute to the pathogenesis of Crohn's Disease. Dysbiosis, or the imbalance of beneficial and harmful bacteria, has been linked to increased intestinal permeability, heightened immune responses, and chronic inflammation characteristic of Crohn's. Studies focus on identifying specific bacterial strains that are depleted or overrepresented in affected individuals and understanding how these changes influence disease progression. Additionally, researchers investigate the potential of probiotics, prebiotics, and fecal microbiota transplantation as therapeutic strategies to restore a healthy microbiome balance. Insights gained from microbiome research are crucial for developing novel interventions aimed at preventing disease flare-ups and promoting long-term remission in Crohn's Disease patients.