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- Table of Contents
Tryptase alpha/beta-1 Antibodies
AND TPSAB1 ELISA kits, Tryptase alpha/beta-1 Proteins
Many biological assays use antibodies to detect Tryptase alpha/beta-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tryptase alpha/beta-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tryptase alpha/beta-1 antibodies...
Designing a Western blot for Tryptase alpha/beta-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TPSAB1 Western Blot GuideDesigning an IHC experiment for Tryptase alpha/beta-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TPSAB1 IHC GuideTPSAB1 Infographic by Boster Bio
All TPSAB1 Products
Product
Figures
Specificity
Applications
Price
Human Tryptase/TPSAB1,B2 ELISA Kit PicoKine®
6 Citations
Human
ELISA
$450
Cat # EK0898
96 wells/kit, with removable strips.
Cat # EK0898
96 wells/kit, with removable strips.
Human
ELISA
$500
Cat # EZ0898
For 5 plates, 96 wells each
Cat # EZ0898
For 5 plates, 96 wells each
Human
IHC, WB, ELISA (Cap)
$370
Cat # PB10016
100 μg/vial
Cat # PB10016
100 μg/vial
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M08039
100 μl
Cat # M08039
100 μl
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07399
100 μg
Cat # M07399
100 μg
TPSAB1 Overview
Facts about Tryptase alpha/beta-1.
Tryptase alpha/beta-1 (TPSAB1)
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of the cell type. May play a role in innate immunity.
Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). .
Gene Information
| Human | |
|---|---|
| Gene Name: | TPSAB1 |
| Uniprot: | Q15661 |
| Entrez: | 7177 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
alpha-Tryptase; TPS1; TPS2; TPSAB1; TPSB1; Tryptase 1; Tryptase alpha; tryptase alpha/beta 1
Molecular Weight
Mass (kDA):
30.515 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (1240705..1242554) |
Tissue Specificity
Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
Subcellular Localizations
Secreted. Released from the secretory granules upon mast cell activation.
Diseases
- Inflammation
- Anaphylaxis
- Asthma
- Mastocytosis
- Hyperplasia
- Fibrosis
- Neoplasms
- Inflammatory Response
- Allergy
- Tumor Angiogenesis
- Bronchial Hyperreactivity
- Edema
Interacting Proteins
- NCK1
- PIK3R1
Pathways
- Cell Activation
- Anaphylaxis
- Pathogenesis
- Mast Cell Activation
- Secretion
- Proteolysis
- Inflammatory Response
- Cell Differentiation
- Hypersensitivity
- Cell Development
- Coagulation
- Mast Cell Differentiation
- Angiogenesis
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPSAB1
bosterbio.com/bosterbio-gene-info-cards/TPSAB1
References
PMID: 2677049 by Miller J.S., et al. Cloning and characterization of complementary DNA for human tryptase.
PMID: 2187193 by Vanderslice P., et al. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
4 Publications of Boster Tryptase alpha/beta-1 Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41598-021-86179-1, Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exace...
- PubMed ID: -, Shih-Lung Cheng,Ching-Hsiung Lin,Sheng-Hao Lin et al.Blood tryptase and thymic s...
- PubMed ID: 24735816, Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synt...
- PubMed ID: 30090343, Acute exposure of ozone induced pulmonary injury and the protective role of vita...
*More publications can be found for each product on its corresponding product page