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- Table of Contents
CLDN1 antibody (A01585-1) performs well in ELISA, IF, ICC, WB and shows reactivity with Human, Rat.
- Validated for inter-lot consistency, specificity, and reproducibility
- Committed to quality since 1993
- Over 3 Publications
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Immunofluorescence Validation of CLDN1 in HepG2 Cells
Immunofluorescent analysis of 4% paraformaldehyde-fixed HepG2 cells labeling CLDN1 with A01585-1 at 20 μg/mL, followed by goat anti-rabbit IgG secondary antibody at 1/500 dilution (green) and DAPI staining (blue).
Immunofluorescent analysis of 4% paraformaldehyde-fixed HepG2 cells labeling CLDN1 with A01585-1 at 20 μg/mL, followed by goat anti-rabbit IgG secondary antibody at 1/500 dilution (green) and DAPI staining (blue).
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Anti-Claudin-1 CLDN1 Antibody
CLDN1 antibody
| Reactive Species | Host | Application |
|---|---|---|
| Human, Rat | Rabbit | ELISA, IF, ICC, WB |
Recommend Dilution
Application
Dilution
Species
WB: 1-2 μg/mL; ICC: 5 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human and rat samples; Immunocytochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
* It is recommended to optimize the amount of this reagent in each experimental system to achieve the best results.
Product Information
Product Name
Anti-Claudin-1 CLDN1 Antibody
View all CLDN1 Antibodies
View all CLDN1 Antibodies
Form
Liquid
Uniprot
Gene ID
Storage & Handling
CLDN1 antibody can be stored at 4°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Host
Rabbit
Contents
CLDN1 Antibody is supplied in PBS containing ≤0.09% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Anti-CLDN1 antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human CLDN1. The immunogen is located within the last 50 amino acids of CLDN1.
Observed Molecular Weight
68 kDa
Calculated Molecular Weight
22.7 kDa
Background of CLDN1
Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.
Cite This Product
Anti-Claudin-1 CLDN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01585-1)
Publications
Application:
Species:
Qing-qing Zhang,Ye Yang,Rong-rong Ren,Qing-qing Chen,Jing-jing Wu,Yu-yu Zheng,Xiao-hui Hou,Yu-feng Zhang,Ming-song Xue,Deng-ke Yin,Self-assembled aggregations in Coptis chinensis decoction dynamically regulate intestinal tissue permeability through peyer‘s patch-associated immunity,Chinese Herbal Medicines,2021,,ISSN 1674-6384,https://doi.org/10.1016/j.chmed.2021.06.004.
Species: Rat
PMID: -
Xiaozhu Tian,Rong Li,Yiming Jiang,Fei Zhao,Zhengsheng Yu,Yiqing Wang,Zixing Dong,Pu Liu,Xiangkai Li,Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake,J
Species: Mouse
PMID: -
Xin-li Liang,Miao-miao Ji,Lai Chen,Ye Liao,Xiao-qiang Kong,Xi-qiang Xu,Zheng-gen Liao,Danny W. Wilson, Traditional Chinese herbal medicine Astragalus Radix and its effects on intestinal absorption of aconite alkaloids in rats, Chinese Herbal Medicines,202
Species: Rat
PMID: -
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Product Promise
We promise Anti-Claudin-1 CLDN1 Antibody performs excellently in relevant applications for ELISA, IF, ICC, WB. If it doesn't perform as promised, we will refund the product. Learn more
In stock
Order Product
A01585-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$481.00
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Guaranteed product quality
We promise all of our products perform as described in datasheets.
This product is for Research Use Only. Not for use in diagnostic procedures.
Update date:
Oct 7, 2026