Rabbit IgG polyclonal antibody for Opioid-binding protein/cell adhesion molecule(OPCML) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Cited in 1 publication(s).
Anti-OPCML Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
CDK16 is a member of the CDK family of serine/threonine protein kinases which are known to regulate the cell cycle. These proteins have a core kinase domain flanked by unique amino- and carboxy- terminal domains. CDK16, which is expressed mainly in mammalian brain, cooperates with an assortment of proteins, and is a part of a multiple signal transduction cascade.
|Product Name||Anti-OPCML Antibody
See all OBCAM/OPCML primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for OBCAM/OPCML detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. OBCAM/OPCML information: Molecular Weight: 38008 MW; Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .|
|Cite This Product||Anti-OPCML Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1131)|
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|Anti-OPCML Antibody may replace the following items: sc 26122|sc 26123|sc 99156.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human OPCML(294-312aa YTCVATNKLGNTNASITLY), identical to the related rat and mouse sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For OPCML (Source: Uniprot.org, NCBI)
|NCBI Gene Id||4978|
|Species Of This Entry||Human|
|Protein Name||Opioid-binding protein/cell adhesion molecule|
|Alternative Names||OBCAM/OPCML|IgLON family member 1; IGLON1opioid-binding protein/cell adhesion molecule-like; OBCAM; OBCAMopiate binding-cell adhesion molecule; OPCM; OPCML; opioid binding protein/cell adhesion molecule-like preprotein; opioid binding protein/cell adhesion molecule-like; Opioid-binding cell adhesion molecule; opioid-binding protein/cell adhesion molecule|
|Post Tranlational Modifications||Methylation; Glycosylation; Demethylation; Ribosylation; Deglycosylation|
|Subcellular Localization||Cell membrane; Lipid-anchor, GPI-anchor.|
|Gene Location||11q25, on Chromasome 11, gene sequence: NC_000011.10 (132403361..133532534, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For OPCML (Source: Uniprot.org, NCBI)
|Protein Function||Binds opioids in the presence of acidic lipids; probably involved in cell contact.|
|Related Diseases||Tissue Adhesions; Neoplasms; Malignant Neoplasms; Carcinoma; Ovarian Neoplasm; Malignant Neoplasm Of Ovary; Epithelial Ovarian Cancer; Nervousness; Malignant Neoplasm Of Lung; Neoplasm Metastasis; Carcinogenesis; Lung Neoplasms; Neuroblastoma; Lymphatic Metastasis; Glioma; Cell Transformation, Neoplastic; Cholangiocarcinoma; Adenocarcinoma; Neoplasm Recurrence, Local; Liver Carcinoma|
|Related Pathways||Cell Adhesion; Methylation; Localization; Dna Methylation; Dna Hypermethylation; Demethylation; Cell Proliferation; Cell-cell Recognition; Gene Silencing; Glycosylation; Dna Hypomethylation; Endocytosis; Ovulation; Axon Guidance; Cellular Localization; Cell Cycle; Hatching; Cell Growth; Pathogenesis; Exocytosis|
|Background||Opioid-binding protein/cell adhesion molecule-like(OPCML),(also called opioid-binding cell adhesion molecule(OBCAM). OPCML is a member of the IgLON family of immunoglobulin(Ig) domain-containing glycosylphosphatidylinositol(GPI)-anchored cell adhesion molecules, as an excellent candidate for the 11q25 ovarian cancer TSG in EOC. The OPCML gene comprises 7 exons, spans approximately 600 kb, and is transcribed from telomere to centromere . And due to the lack of transmembrane domains necessary for signal transduction, it is improbable that OBCAM acts independently as an opioid receptor; more likely, it plays an important accessory role in opioid receptor function.|
|Scientific References||PMID: 7721093 by Shark K.B., et al. Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).|
PMID: 12819783 by Sellar G.C., et al. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.
Our Boster Quality Guarantee for Anti-OPCML Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
WB: Rat Brain Tissue Lysate
IHC(P): Human Mammary Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Total number of citations: 1
|Wang L, Zhu Js, Song Mq, Chen Gq, Chen Jl. World J Gastroenterol. 2006 Nov 21;12(43):6949-54. Comparison Of Gene Expression Profiles Between Primary Tumor And Metastatic Lesions In Gastric Cancer Patients Using Laser Microdissection And Cdna Micro...||PubMed ID 17109515|
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