Introduction
CDK16 is a member of the CDK family of serine/threonine protein kinases which are known to regulate the cell cycle. These proteins have a core kinase domain flanked by unique amino- and carboxy- terminal domains. CDK16, which is expressed mainly in mammalian brain, cooperates with an assortment of proteins, and is a part of a multiple signal transduction cascade.
Overview
| Product Name |
Anti-OPCML Antibody
See all OBCAM/OPCML primary antibodies, ELISA kits and proteins |
| SKU/Catalog Number |
PA1131 |
| Pack Size |
100μg/vial |
| Storage & Handling |
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing. |
| Description |
Polyclonal antibody for OBCAM/OPCML detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. OBCAM/OPCML information: Molecular Weight: 38008 MW; Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . |
| Cite This Product |
Anti-OPCML Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1131)
|
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Anti-OPCML Antibody may replace the following items: sc 26122|sc 26123|sc 99156. |
Product Specs
| Host |
Rabbit |
| Reactivity/Species |
Human, Mouse, Rat |
| Predicted Reactivity |
Hamster
*This antibody is predicted to react with the above species based on antigen
sequence similarities. Our Boster Guarantee covers the use of this product with the above species. |
| Applications |
IHC, WB
*Our Boster Guarantee covers the use of this product in the above
tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products. |
| Related Products |
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round. |
| Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human OPCML(294-312aa YTCVATNKLGNTNASITLY), identical to the related rat and mouse sequences. |
| Cross Reactivity |
No cross reactivity with other proteins |
Gene/Protein Basic Information For OPCML (Source: Uniprot.org, NCBI)
| Uniprot Id | Q14982 |
|---|
| NCBI Gene Id | 4978 |
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| Species Of This Entry | Human |
|---|
| Gene Name | OPCML |
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| Protein Name | Opioid-binding protein/cell adhesion molecule |
|---|
| Superfamily | immunoglobulin superfamily |
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| Alternative Names | OBCAM/OPCML|IgLON family member 1; IGLON1opioid-binding protein/cell adhesion molecule-like; OBCAM; OBCAMopiate binding-cell adhesion molecule; OPCM; OPCML; opioid binding protein/cell adhesion molecule-like preprotein; opioid binding protein/cell adhesion molecule-like; Opioid-binding cell adhesion molecule; opioid-binding protein/cell adhesion molecule |
|---|
| Molecular Weight | 38008 |
|---|
| Post Tranlational Modifications | Methylation; Glycosylation; Demethylation; Ribosylation; Deglycosylation |
|---|
| Subcellular Localization | Cell membrane; Lipid-anchor, GPI-anchor. |
|---|
| Gene Location | 11q25, on Chromasome 11, gene sequence: NC_000011.10 (132403361..133532534, complement) |
|---|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For OPCML (Source: Uniprot.org, NCBI)
| Protein Function | Binds opioids in the presence of acidic lipids; probably involved in cell contact. |
|---|
| Related Diseases | Tissue Adhesions; Neoplasms; Malignant Neoplasms; Carcinoma; Ovarian Neoplasm; Malignant Neoplasm Of Ovary; Epithelial Ovarian Cancer; Nervousness; Malignant Neoplasm Of Lung; Neoplasm Metastasis; Carcinogenesis; Lung Neoplasms; Neuroblastoma; Lymphatic Metastasis; Glioma; Cell Transformation, Neoplastic; Cholangiocarcinoma; Adenocarcinoma; Neoplasm Recurrence, Local; Liver Carcinoma |
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| Related Pathways | Cell Adhesion; Methylation; Localization; Dna Methylation; Dna Hypermethylation; Demethylation; Cell Proliferation; Cell-cell Recognition; Gene Silencing; Glycosylation; Dna Hypomethylation; Endocytosis; Ovulation; Axon Guidance; Cellular Localization; Cell Cycle; Hatching; Cell Growth; Pathogenesis; Exocytosis |
|---|
| Background | Opioid-binding protein/cell adhesion molecule-like(OPCML),(also called opioid-binding cell adhesion molecule(OBCAM). OPCML is a member of the IgLON family of immunoglobulin(Ig) domain-containing glycosylphosphatidylinositol(GPI)-anchored cell adhesion molecules, as an excellent candidate for the 11q25 ovarian cancer TSG in EOC. The OPCML gene comprises 7 exons, spans approximately 600 kb, and is transcribed from telomere to centromere . And due to the lack of transmembrane domains necessary for signal transduction, it is improbable that OBCAM acts independently as an opioid receptor; more likely, it plays an important accessory role in opioid receptor function. |
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| Scientific References | PMID: 7721093 by Shark K.B., et al. Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).
PMID: 12819783 by Sellar G.C., et al. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. |
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Our Boster Quality Guarantee for Anti-OPCML Antibody covers its use in the following applications.
Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Anti-OPCML antibody, PA1131, Western blotting
WB: Rat Brain Tissue Lysate
Anti-OPCML antibody, PA1131, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Specific Protocols
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
See all OBCAM/OPCML primary antibodies,
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Total number of citations: 1
| Wang L, Zhu Js, Song Mq, Chen Gq, Chen Jl. World J Gastroenterol. 2006 Nov 21;12(43):6949-54. Comparison Of Gene Expression Profiles Between Primary Tumor And Metastatic Lesions In Gastric Cancer Patients Using Laser Microdissection And Cdna Micro... |
PubMed ID 17109515 |
