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May exert a protective role on endothelial cells through an endocrine action. It's directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity.
|Sequence:||19; NC_000019.10 (8364129..8374373)|
Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Secreted. Secreted, extracellular space, extracellular matrix. The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable).
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