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- Table of Contents
Aquaporin-2 Antibodies
AND AQP2 ELISA kits, Aquaporin-2 Proteins
Many biological assays use antibodies to detect Aquaporin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aquaporin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aquaporin-2 antibodies...
Designing a Western blot for Aquaporin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AQP2 Western Blot GuideAQP2 Infographic by Boster Bio
All AQP2 Products
Product
Figures
Specificity
Applications
Price
Anti-Aquaporin 2/AQP2 Antibody Picoband®
6 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9474
100 μg/vial
Cat # PB9474
100 μg/vial
Anti-Aquaporin 2/AQP2 Antibody Picoband®
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1742
100 μg/vial
Cat # PA1742
100 μg/vial
AQP2 Overview
Facts about Aquaporin-2.
Aquaporin-2 (AQP2)
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. .
Gene Information
| Human | |
|---|---|
| Gene Name: | AQP2 |
| Uniprot: | P41181 |
| Entrez: | 359 |
Family
| Belongs to: |
|---|
| MIP/aquaporin (TC 1.A.8) family |
Alternative Names
ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD
Molecular Weight
Mass (kDA):
28.837 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.12 |
| Sequence: | 12; NC_000012.12 (49950737..49958878) |
Tissue Specificity
Expressed in renal collecting tubules.
Subcellular Localizations
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity).
Diseases
- Diabetes Mellitus
- Nephrogenic Diabetes Insipidus
- Disease Of Adrenal Medulla
- Polyuria
- Dehydration
- Kidney Diseases
- Deprivation Of Water
- Edema
- Heart Failure
- Congenital Nephrogenic Diabetes Insipidus
- Anti-diuresis (finding)
- Kidney Failure
Pathways
- Excretion
- Transport
- Localization
- Water Transport
- Secretion
- Water Homeostasis
- Endocytosis
- Diuresis
- Glomerular Filtration
- Pathogenesis
- Exocytosis
- Natriuresis
- Fluid Transport
PTMs
- Phosphorylation
- Glycosylation
- Biotinylation
- Dephosphorylation
- Ubiquitination
Research Areas
- Plasma Membrane Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AQP2
bosterbio.com/bosterbio-gene-info-cards/AQP2
References
PMID: 8140421 by Deen P.M.T., et al. Requirement of human renal water channel aquaporin-2 for vasopressin- dependent concentration of urine.
PMID: 7522228 by Uchida S., et al. Isolation of human aquaporin-CD gene.
5 Publications of Boster Aquaporin-2 Antibodies & ELISA Kits
- PubMed ID: 10.1111/j.1440-1681.2011.05481.x, Effect of exercise training on renal function and renal aquaporin‐2 expression...
- PubMed ID: 10.1080/01443615.2017.1327516, Expression and significance of aquaporin-2 and serum hormones in placenta of pat...
- PubMed ID: 10.1016/j.transproceed.2010.02.070, The Changes of Aquaporin 2 in the Graft of Acute Rejection Rat Renal Transplanta...
- PubMed ID: 26261083, Expression pattern of aquaporins in patients with primary nephrotic syndrome wit...
- PubMed ID: 21824173, Cui Wy, Tian Ay, Bai T. Clin Exp Pharmacol Physiol. 2011 Nov;38(11):747-54. Doi:...
*More publications can be found for each product on its corresponding product page