ATG7 Antibodies

Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins due to their conjugation with phosphatidylethanolamine. Both systems are necessary for the ATG8 institution to Cvt vesicles and autophagosomes membranes.

Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which leads to modulate adrenal quantity and quality by removing the mitochondria to a basal level to meet cellular energy demands and preventing excess ROS production.

Gene Information

Human
Gene Name:	ATG7
Uniprot:	O95352
Entrez:	10533

Family

Belongs to:
ATG7 family

Alternative Names

APG7 autophagy 7-like (S. cerevisiae); APG7; APG7L; APG7-LIKE; ATG12-activating enzyme E1 ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); ATG7; Autophagy-related protein 7; DKFZp434N0735; GSA7; hAGP7; ubiquitin activating enzyme E1-like protein; Ubiquitin-activating enzyme E1-like protein; ubiquitin-like modifier-activating enzyme ATG7

Molecular Weight

Mass (kDA):
77.96 kDA

Genomic Context

Human
Location:	3p25.3
Sequence:	3; NC_000003.12 (11272348..11564652)

Tissue Specificity

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.

Subcellular Localizations

Cytoplasm. Preautophagosomal structure. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.

Diseases

• Malignant Neoplasms
• Neoplasms
• Nerve Degeneration
• Carcinoma
• Leukemia
• Neurodegenerative Disorders
• Liver Carcinoma
• Obesity
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Liver Neoplasms
• Inflammation
• Insulin Resistance

• Diabetes Mellitus
• Myeloid Leukemia
• Cell Transformation, Neoplastic
• Hypoxia
• Hepatitis
• Malignant Paraganglionic Neoplasm
• Parkinson Disease

Interacting Proteins

• EEF1D
• GABARAP
• GABARAPL1
• GABARAPL2
• IRF2

• MAP1LC3B
• SIRT1
• TP53

Pathways

• Autophagy
• Cell Death
• Conjugation
• Macroautophagy
• Autophagic Cell Death
• Pathogenesis
• Cellular Homeostasis
• Programmed Cell Death
• Transport
• Localization
• Secretion
• Aging
• Cell Cycle

• Proteolysis
• Rna Interference
• Cell Proliferation
• Cell Growth
• Senescence
• Cellular Process
• Immune Response

PTMs

• Phosphorylation
• Cleavage
• Ubiquitination
• Acetylation
• Dephosphorylation
• Reduction
• Acylation

• Prenylation
• Biotinylation
• Nitration
• Glycosylation
• Deacetylation
• Oxidation
• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATG7

Best Uses Of The ATG7 Marker From Boster Bio

This article will discuss the benefits of using the ATG7 Marker and the primary-secondary-ABC system from Boster Bio. It will also discuss how Super Vision Detection Kits from Boster Bio enable researchers to identify specific proteins of interest with low background, high specificity, and low noise. It will also explain the benefits of the ATG7 Marker itself. It will conclude with most efficient uses of the ATG7 Marker in a broad variety of applications.

Boster Bio's primary-secondary-ABC system allows researchers to locate the proteins of interest with low background and high specificity

Boster Bio produces a wide variety of recombinant proteins as well as reagents to aid in research in the field of immunology. These enzymes target a wide range of targets that can be druggable, such as peptidases, phosphodiesterases, as well as poly ADP-ribose Polymerases and Ubiquitin Enzymes and Immuno Checkpoint proteins. In addition to the primary-secondary-ABC system, Boster Bio also manufactures a variety of recombinant protein and cell lines for immunological studies, as well as ELISA kits.

Finding protein targets within the cell membrane is among the biggest problems in discovery of drugs. Boster Bio's primary-secondary-ABC system eliminates the need for toxic metal-based reagents. It gives researchers low background and a high-specific method for identifying proteins of interest in target cells.

Another instance of an innovative delivery system is the use of RNAi to detect autoimmune disease gene variants. Dr. John Ray of the Benaroya Research Institute in Seattle has used this method to find six genes whose variations might be the cause of an individual's autoimmune disorder. Researchers using this technology can now identify which gene variants are the cause of autoimmune disease and how they could influence the immune system of a patient.

Boster Biologicals' technology platform is scalable, allowing for the production of consistent batches for each human cell. This new technology can enable researchers to study human diseases using cell therapies and drugs. These antibody kits can detect biomarkers for inflammation, cancer or other illnesses. The sensitivity of PICOKINE(tm), ELISA kits is picogram-level.

Recent research conducted by BRI scientists was conducted in collaboration with researchers from the University of Washington as well as the Seattle Children's Research Institute. They discovered that the oligoadenylate synthetase protein has a better access to viral replication sites, and consequently increased antiviral activity. This protein is also essential in the development of vaccines for diseases like SARS-CoV-2 and COVID-19. These findings suggest that COVID-19's reproduction can be prevented early in order to prevent severe disease.

BRI has recently launched the Sound Life Project, which is a two-year study that studies healthy immune systems. The aim is to develop an accurate representation of the immune system of a person. Researchers hope to discover a cure using vast amounts of data collected over many years.

A breakthrough in immunology involves gene-editing CD4+ T cells to develop a new line of defense against viruses including Ebola and COVID-19. This unique platform activates genes throughout the genome, and is both fast and cheap. It can be used to investigate a variety of species of cells and organisms, leading to a new therapeutic target.

This method has a number of advantages over the current immunotherapy treatments. It lets researchers identify the proteins of interest with low background, high specificity, and also allows them to perform immunoassays using proteins. This technique can be utilized by researchers to target proteins of interest with high specificity and low background.

Boster Bio's Super Vision Detection kits allows researchers to locate the proteins of interest using low background and high specificity

This new technology allows researchers to find proteins of interest rapidly and with low background. Researchers can also make use of Boster Bio's Super Vision Detection kits to study the binding characteristics of proteins in living cells. These kits have an excellent level of specificity that allows researchers to find proteins of interest with high sensitivity. This reduces the possibility of false negatives.

The Test for IL-6 is one the most frequently used antibodies for COVID-19. It measures the amount of IgG antibodies that are present in plasma or serum. Researchers can also make use of this assay to identify spike proteins and SARS-CoV-2 nucleocapsid proteins. The kit has been approved by the Indian Council of Medical Research.

The sensitivity of FebriDx was 93% for COVID-19 in 251 patients admitted to hospitals. With high sensitivity and sensitivity this kit can be utilized as a front-door triage device in hospitals. The company says that this technology can be utilized by health care professionals in low-income countries. The company plans to market the test in various countries, and also training healthcare professionals across 50 countries.

The ability of the SARS-CoV-2-specific memory cells to produce antibodies against the spike protein was evaluated in this study. The majority of patients showed positive results for both the RBD IgG spike and the SARS-CoV-2 surge. Both of these approaches are compatible with each one. In 93% of COVID-19 patients, the RBD-specific memory cells were identified between one and two months after infection.

These tests can be used by researchers to detect the presence of SARS in nasopharyngeal specimens. These tests are the gold standard for COVID-19 diagnostics. Participants in this study give a sample of saliva and send it off to a lab that is certified to be analysed. The results are delivered within three to five days. Many major manufacturers are increasing their testing and production capabilities.

This Omicron variant could alter the test's sensitivity. As such, researchers are rushing to determine the effects of this variant on COVID 19 and SARS. Although these tests are reasonably inexpensive and easy to carry out however, the sensitivity of the tests is not certain to increase. These tests are not suitable for human clinical tests.

Benefits of using the ATG7 Marker

The ATG7 Marker is a cell protein that is involved with autophagy. It is a 703-amino acids part of the E1 enzyme family. Its orthologs found in mice and the rat have 93% of their sequences with human ATG7, but the protein does not possess an Ubiquitin fold domain. However, it does have an ATP binding domain as well as an active site cysteine. Autophagy Related 7 is expressed in bone marrow, kidneys, and lymph nodes.