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- Table of Contents
BMX Antibodies
AND BMX ELISA kits, BMX Proteins
Many biological assays use antibodies to detect BMX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BMX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BMX antibodies...
Designing an IHC experiment for BMX? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BMX IHC GuideBMX Infographic by Boster Bio
All BMX Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1736
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1736
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2195
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2195
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2153
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2153
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1204
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1204
1 kit, containing one 96-well plate and all necessary reagents
BMX Overview
Facts about Cytoplasmic tyrosine-protein kinase BMX.
Cytoplasmic tyrosine-protein kinase BMX (BMX)
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation.
Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a crucial role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor households essential for angiogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | BMX |
| Uniprot: | P51813 |
| Entrez: | 660 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
BMX non-receptor tyrosine kinase; BMX; Bone marrow tyrosine kinase gene in chromosome X protein; EC 2.7.10; EC 2.7.10.2; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; ETKcytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; NTK38; PSCTK2; PSCTK3
Molecular Weight
Mass (kDA):
78.011 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.2 |
| Sequence: | X; NC_000023.11 (15500777..15556519) |
Tissue Specificity
Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
Subcellular Localizations
Cytoplasm. Localizes to the edges of spreading cells when complexed with BCAR1.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Agammaglobulinemia
- Tumor Angiogenesis
- X-linked Agammaglobulinemia
- Immunologic Deficiency Syndromes
- Athletic Injuries
- Carcinoma
- Tissue Adhesions
- Pathologic Neovascularization
Interacting Proteins
- PIM1
- STAT3
Pathways
- Angiogenesis
- Cell Migration
- Localization
- Cell Proliferation
- Tube Formation
- Secretion
- Response To Ischemia
- Cell Growth
- Cell Adhesion
- Cell Motility
- Inflammatory Response
- Drug Resistance
- Cytokine Production
PTMs
- Phosphorylation
- Cleavage
- Acetylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BMX
bosterbio.com/bosterbio-gene-info-cards/BMX
References
PMID: 7970727 by Tamagnone L., et al. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
PMID: 9520419 by Qiu Y., et al. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.