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- Table of Contents
Facts about Cytoplasmic tyrosine-protein kinase BMX.
Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a crucial role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor households essential for angiogenesis.
Human | |
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Gene Name: | BMX |
Uniprot: | P51813 |
Entrez: | 660 |
Belongs to: |
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protein kinase superfamily |
BMX non-receptor tyrosine kinase; BMX; Bone marrow tyrosine kinase gene in chromosome X protein; EC 2.7.10; EC 2.7.10.2; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; ETKcytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; NTK38; PSCTK2; PSCTK3
Mass (kDA):
78.011 kDA
Human | |
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Location: | Xp22.2 |
Sequence: | X; NC_000023.11 (15500777..15556519) |
Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
Cytoplasm. Localizes to the edges of spreading cells when complexed with BCAR1.
PMID: 7970727 by Tamagnone L., et al. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
PMID: 9520419 by Qiu Y., et al. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.