Product Info Summary
SKU: | A02537Y43 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IF, IHC |
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Product info
Product Name
Anti-ETK (Y43) BMX Antibody
SKU/Catalog Number
A02537Y43
Size
100ul
Form
Liquid
Description
Boster Bio Anti-ETK (Y43) BMX Antibody catalog # A02537Y43. Tested in IHC,IF applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-ETK (Y43) BMX Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02537Y43)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Bmx around the phosphorylation site of Y40.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02537Y43 is reactive to BMX in Human, Mouse, Rat
Applications
A02537Y43 is guaranteed for IF, IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
78.011kDa
Background of BMX
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Tamagnone L., Oncogene 9:3683-3688(1994).
Qiu Y., Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).
Fuortes M., Thesis (1994), Cornell University, United States.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
IF: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of BMX using Anti-ETK (Y43) BMX Antibody (A02537Y43).
Immunohistochemistry (IHC) analyzes of ETK (Y43) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For BMX (Source: Uniprot.org, NCBI)
Gene Name
BMX
Full Name
Cytoplasmic tyrosine-protein kinase BMX
Weight
78.011kDa
Superfamily
protein kinase superfamily
Alternative Names
BMX non-receptor tyrosine kinase; BMX; Bone marrow tyrosine kinase gene in chromosome X protein; EC 2.7.10; EC 2.7.10.2; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; ETKcytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; NTK38; PSCTK2; PSCTK3 BMX ETK, PSCTK2, PSCTK3 BMX non-receptor tyrosine kinase cytoplasmic tyrosine-protein kinase BMX|BTK-like on X chromosome|Etk/Bmx cytosolic tyrosine kinase|NTK38 tyrosine kinase|bone marrow tyrosine kinase gene in chromosome X protein|epithelial and endothelial tyrosine kinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on BMX, check out the BMX Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BMX: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ETK (Y43) BMX Antibody (A02537Y43)
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No publications found for A02537Y43
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