C-C motif chemokine 14 Antibodies

C-C motif chemokine 14 (CCL14)

Has weak activities on human monocytes and acts through receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is dormant on T-lymphocytes, neutrophils, and eosinophil leukocytes.

Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Gene Information

Human
Gene Name:	CCL14
Uniprot:	Q16627
Entrez:	6358

Family

Belongs to:
intercrine beta (chemokine CC) family

Alternative Names

C-C motif chemokine 14; CCL14; chemokine (C-C motif) ligand 14; Chemokine CC-1/CC-3; chemokine CC-3; CKB1; FLJ16015; HCC-1; HCC-1(1-74); HCC-1/HCC-3; HCC-3; hemofiltrate CC chemokine 1; MCIF; member 14; NCC2CC-1; NCC-2CKb1; new CC chemokine 2; SCYA14CC-3; Small-inducible cytokine A14

Molecular Weight

Mass (kDA):
10.678 kDA

Genomic Context

Human
Location:	17q12
Sequence:	17; NC_000017.11 (35983288..35986729, complement)

Tissue Specificity

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.

Subcellular Localizations

Secreted.

Diseases

• Cholangiocarcinoma
• Neoplasms
• Malignant Neoplasms
• Inflammation
• Hiv Infections
• Cell Invasion
• Neoplasm Metastasis
• Tumor Angiogenesis
• Endometrial Polyp
• Leukemia
• Acquired Immunodeficiency Syndrome
• Immunologic Deficiency Syndromes
• Liver Carcinoma

• Allergic Asthma
• Asthma
• Tissue Adhesions
• Autoimmune Reaction
• Sclerosis
• Epithelial Metaplasia
• Arthritis, Reactive

Pathways

• Chemotaxis
• Cell Migration
• Embryo Implantation
• Angiogenesis
• Pathogenesis
• Immune Response
• Leukocyte Migration
• Cell Proliferation
• Induction Of Apoptosis
• Proteolysis
• Dna Repair
• Adaptive Immune Response
• Lymphocyte Migration

• Humoral Immune Response
• Decidualization
• Keratinocyte Migration
• Chemokine Secretion
• Blastocyst Development
• Regulation Of Angiogenesis
• Regulation Of Chemokine Activity

PTMs

• Cleavage
• Demethylation

• Glycosylation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCL14

Boster Bio: Best Uses Of The Caspase-Active Protein (CCL14) Marker

Scientists have many options for using the Boster Biography: Best Uses Of CCL14 Marker. It can be used in measuring CCL14 levels across a range of tissues, including breast, liver and kidney. Scientists from all over the world can submit their results to receive species-specific or application-specific samples. Boster scientists can also get product credits for the results they produce. This policy is available to all scientists, regardless where they live.

Anti-CCL14 Antibody Picoband

The AntiCCL14 Antibody PicoBand from Boster Bio reacts positively with Human, Mouse and Rat. The inactive ingredients include Trehalose, NaCl and Na2HPO4 The product is stable at -20degC for up to one year and four degrees for one month. Avoid prolonged storage in a refrigerator to achieve the best results.

The RAB14 chemokine gene encodes a member CC chemokine families, a group small secreted proteins characterized with two adjacent cysteines. RAB14 promotes intracellular trafficking and acts a molecular switches. It also recruits downstream affector proteins onto membranes. Boster antibodies can be produced by testing samples against known negative and positive control proteins. They are validated to detect presence of the receptor within specific cells.

Clinical applications

CCL14 can be used to detect inflammatory renal disease. The marker correlates with gene markers of T cells and monocytes. The CCL14 gene marker is also associated with gene markers for neutrophils, DCs, STAT5B. Although the mechanism by which CCL14 gene is regulated is not known, it could be a contributing factor to inflammatory kidney disease. It has been linked with T cell division.

CCL14 can also be used to predict HCC. CCL14 expression in tumor tissue correlates to immune cell infiltration. Low levels of CCL14 could indicate a greater risk of relapse. Patients with advanced cancer may require close medical supervision if their CCL14 levels are low. This marker is currently not available for clinical application in all types cancers. However, it is associated with the immune response and is still undergoing study.

CCL14 also correlates with immune cell infiltration in different cancer types. Expression of CCL14 correlates with the level of tumor-infiltrating immune cells in 15 cancer types. CCL14 expression is also associated with the presence of monocytes, dendritic cells, and macrophages in 17 types of tumor. These results are promising and are expected to help physicians select the appropriate treatment for the patients.

CCL14 is used clinically to diagnose inflammatory bowel disease or cancer. Researchers in the United States have found that low CCL14 gene expression is associated to poorer OS and PFS among cancer patients. Low CCL14-mRNA levels have also been associated with a higher risk of vascular intrusion in cancer. CCL14 is not associated with early-stage HCC or hepatitis virus infections.

CCL14 expression has been shown correlate with cancer prognosis in patients with hepatocellular carcinoma. Kaplan-Meier plotter analysis showed that CCL14 expression was associated with better OS, PFS and RFS than low levels in HCC. Moreover, high CCL14 expression is associated with poor DFS and PS in gastric cancer patients. This gene can be used to detect hepatitis, and other cancers.

The urine CCL14 marker has been validated in critically ill patients with established AKI. The Ruby study established cutoffs to measure this biomarker. Patients who received renal replacement therapy within 72hrs or died before the endpoint were considered to have reached that point. These are the study's cutoffs:

References

The CCL14 protein is an important regulator of trophoblast adhesiveness. However, its role is not entirely clear, as its effects vary depending on the cell type and donor. In this article, we'll examine some references to the CCL14 marker. We'll be discussing the role of CCL14 in cancer research. There are many other uses for the CCL14 marker. Here are some examples.

CCL14 molecules can activate monocytes. macrophages. THP-1 cells. It is thought to bind to the CCR3 and CCR5 receptors and may contribute to pathogenesis of a number of diseases. High levels of this cytokine may cause some cancers and allergic asthma inflammation. However, research is still needed to determine its role in the immune response to cancer.