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- Table of Contents
Cyclin-A2 Antibodies
AND CCNA2 ELISA kits, Cyclin-A2 Proteins
Many biological assays use antibodies to detect Cyclin-A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-A2 antibodies...
Designing a Western blot for Cyclin-A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CCNA2 Western Blot GuideDesigning an IHC experiment for Cyclin-A2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CCNA2 IHC GuideCCNA2 Infographic by Boster Bio
All CCNA2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9424
100 μg/vial
Cat # PB9424
100 μg/vial
Bovine, Human, Mouse
ICC, WB
$370
Cat # MA1032
100 μg/vial
Cat # MA1032
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00700-1
100 μl
Cat # M00700-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00700-3
20μL, 40μL, 100μL, 200μL
Cat # M00700-3
20μL, 40μL, 100μL, 200μL
CCNA2 Overview
Facts about Cyclin-A2.
Cyclin-A2 (CCNA2)
Cyclin which controls both the G1/S and the G2/M transition stages of the cell cycle. Functions through the formation of particular serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2.
The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 through the cell cycle. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CCNA2 |
| Uniprot: | P20248 |
| Entrez: | 890 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
CCN1CCNAcyclin-A; CCNA; CCNA2; Cyclin A2; Cyclin-A; cyclin-A2
Molecular Weight
Mass (kDA):
48.551 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q27 |
| Sequence: | 4; NC_000004.12 (121816444..121823883, complement) |
Subcellular Localizations
Nucleus. Cytoplasm. Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Retinoblastoma
- Adenocarcinoma
- Liver Carcinoma
- Malignant Paraganglionic Neoplasm
- Hyperplasia
- Malignant Neoplasm Of Lung
Interacting Proteins
- AKT1
- CDK2
- CDKN1A
- CDKN1B
- UHRF2
Pathways
- Cell Cycle
- Cell Proliferation
- Mitosis
- S Phase
- Cell Division
- Cell Cycle Arrest
- Regeneration
- Dna Replication
- Cell Growth
- Localization
- Rna Interference
- Spermatogenesis
- Hepatocyte Proliferation
PTMs
- Phosphorylation
- Methylation
- Sumoylation
Research Areas
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Cellular Markers
- Core ESC-Like Genes
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCNA2
bosterbio.com/bosterbio-gene-info-cards/CCNA2
References
PMID: 1967822 by Wang J., et al. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.
PMID: 8202514 by Henglein B., et al. Structure and cell cycle-regulated transcription of the human cyclin A gene.
11 Publications of Boster Cyclin-A2 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.cbi.2017.07.020, Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite ...
- PubMed ID: 31974617, Wang S,Zhang C,Zhang X.Downregulation of long non‑coding RNA ANRIL promotes pr...
- PubMed ID: 24628936, Activin A induces growth arrest through a SMAD- dependent pathway in hepatic pro...
- PubMed ID: 28749992, Zhang C, Chang C, Zhao W, Gao H, Wang Q, Li D, Zhang F, Zhang S, Xu C,. PLoS One...
- PubMed ID: 28932249, Zhang C, Chang C, Li D, Zhang F, Xu C. Cell Mol Biol Lett. 2017 Sep 16;22:21. do...
- PubMed ID: 25918708, Wang C, Ge Q, Chen Z, Hu J, Li F, Song X, Xu H, Ye Z. Biomed Res Int. 2015;2015:...
- PubMed ID: 23337938, Mao F, Wang B, Xiao Q, Xi G, Sun W, Zhang H, Ye F, Wan F, Guo D, Lei T, Chen X. ...
- PubMed ID: 20878477, Lin P, Fu J, Zhao B, Lin F, Zou H, Liu L, Zhu C, Wang H, Yu X. Mol Biol Rep. 201...
- PubMed ID: 24076388, Deng L, Lu Y, Zhao X, Sun Y, Shi Y, Fan H, Liu C, Zhou J, Nie Y, Wu K, Fan D, Gu...
- PubMed ID: 25151579, Zhao P, Li Y, Gao G, Wang S, Yan Y, Zhan X, Liu Z, Mao Z, Chen S, Wang L. Eur J ...
- PubMed ID: 24194897, Li M, Tian L, Wang L, Yao H, Zhang J, Lu J, Sun Y, Gao X, Xiao H, Liu M. Plos On...
*More publications can be found for each product on its corresponding product page